C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095303 PTGS1 9606 + 9:122370530-122395703 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000223423 PTGS1-002 122371080-122393178 protein_coding
  ENST00000362012 PTGS1-001 122371080-122395703 protein_coding
  ENST00000373698 PTGS1-201 122375322-122395702 protein_coding
  ENST00000426608 PTGS1-003 122371188-122383532 protein_coding
  ENST00000540753 PTGS1-202 122370530-122395702 protein_coding
  ENST00000614910 PTGS1-203 122371005-122395702 protein_coding
  ENST00000619306 PTGS1-204 122371085-122395702 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000223423ENST00000362012ENST00000373698ENST00000540753ENST00000614910
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000223423 1.304±0.00 2.955±0.00 N/A N/A 1.289±0.15 5.594±0.00 0.765±0.04 2.031±1.72 19.410±19.13 2.191±0.49 0.151±0.00 1.704±0.46 1.690±0.55 1.065±0.00
ENST00000362012 N/A N/A 0.527±0.00 0.720±0.00 N/A 11.886±0.00 0.583±0.19 0.826±0.00 34.500±0.00 1.073±0.14 N/A 1.013±0.34 0.661±0.06 0.660±0.36
ENST00000373698 0.299±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000540753 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.948±0.00 N/A N/A N/A N/A
ENST00000614910 0.659±0.00 4.508±0.00 N/A 1.007±0.69 0.242±0.00 5.220±0.00 0.537±0.00 0.838±0.54 0.318±0.00 1.294±0.00 0.421±0.00 1.322±0.00 0.886±0.06 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006NA CIL_0006NA_0001 CGP 9:122264603-122395703

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 ISS prostaglandin biosynthetic process
GO:0001750 IEA photoreceptor outer segment
GO:0004601 TAS:IEA peroxidase activity
GO:0004666 IDA prostaglandin-endoperoxide synthase activity
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006629 NAS lipid metabolic process
GO:0006693 IEA prostaglandin metabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006954 IEA inflammatory response
GO:0006979 IEA response to oxidative stress
GO:0008217 ISS regulation of blood pressure
GO:0019369 TAS arachidonic acid metabolic process
GO:0019371 IDA cyclooxygenase pathway
GO:0020037 IEA heme binding
GO:0042127 IEA regulation of cell proliferation
GO:0043231 ISS intracellular membrane-bounded organelle
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0051213 IEA dioxygenase activity
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052148 ptgs1 prostaglandin-endoperoxide synthase 1 protein_coding Danio_rerio
ENSMUSG00000047250 Ptgs1 prostaglandin-endoperoxide synthase 1 protein_coding Mus_musculus

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