C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000099822 HCN2 9606 + 19:589893-617159 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251287 HCN2-001 589893-617159 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000251287
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000251287 0.155±0.00 0.356±0.00 0.090±0.00 24.527±21.03 0.092±0.00 0.468±0.00 2.588±2.51 1.222±0.00 0.073±0.00 0.129±0.00 0.023±0.00 0.091±0.04 0.245±0.06 4.506±2.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0001 VISTA 19:477571-1083531
CIL_00008I CIL_00008I_0001 CGP 19:571309-617159
CIL_0005ZK CIL_0005ZK_0002 CGP 19:589893-633604

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005216 IEA ion channel activity
GO:0005222 IDA intracellular cAMP activated cation channel activity
GO:0005248 IMP voltage-gated sodium channel activity
GO:0005249 IBA voltage-gated potassium channel activity
GO:0005515 IEA protein binding
GO:0005886 IDA plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006811 IEA ion transport
GO:0007267 TAS cell-cell signaling
GO:0007268 TAS synaptic transmission
GO:0008076 TAS voltage-gated potassium channel complex
GO:0016020 IEA membrane
GO:0030552 IEA cAMP binding
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IMP sodium ion transmembrane transport
GO:0042391 IBA regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0055085 IEA transmembrane transport
GO:0071320 IDA cellular response to cAMP
GO:0071321 IDA cellular response to cGMP
GO:0071805 IBA potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061665 hcn2b hyperpolarization activated cyclic nucleotide-gated potassium channel 2b protein_coding Danio_rerio
ENSDARG00000090115 HCN2 (2 of 2) hyperpolarization activated cyclic nucleotide-gated potassium channel 2 protein_coding Danio_rerio
ENSMUSG00000020331 Hcn2 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 protein_coding Mus_musculus

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