C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020331 Hcn2 10090 + 10:79716634-79736108 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020581 Hcn2-201 79716634-79736108 protein_coding
  ENSMUST00000099513 Hcn2-001 79716634-79736108 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020581ENSMUST00000099513
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020581 N/A 1.918±1.42 N/A 68.643±0.00 0.667±0.13 1.319±0.47 3.416±0.75 0.167±0.01 0.109±0.07 0.407±0.00 0.192±0.00 1.474±0.94 5.006±4.09 0.205±0.16
ENSMUST00000099513 0.654±0.18 4.117±1.43 0.493±0.10 8.423±6.02 0.361±0.12 6.547±0.75 6.678±2.63 0.531±0.16 0.136±0.06 0.900±0.26 0.504±0.16 2.541±0.93 4.204±2.73 0.236±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008XG CIL_0008XG_0002 VISTA 10:79539861-80142369
CIL_00008I CIL_00008I_0002 CGP 10:79704491-79736108
CIL_0005ZK CIL_0005ZK_0003 CGP 10:79716634-79746581

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005222 ISS intracellular cAMP activated cation channel activity
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005249 ISS voltage-gated potassium channel activity
GO:0005515 IPI protein binding
GO:0005886 IEA plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0030552 IEA cAMP binding
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA sodium ion transmembrane transport
GO:0042391 IDA regulation of membrane potential
GO:0042802 IEA identical protein binding
GO:0071320 ISS cellular response to cAMP
GO:0071321 IEA cellular response to cGMP
GO:0071805 ISS potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061665 hcn2b hyperpolarization activated cyclic nucleotide-gated potassium channel 2b protein_coding Danio_rerio
ENSDARG00000090115 HCN2 (2 of 2) hyperpolarization activated cyclic nucleotide-gated potassium channel 2 protein_coding Danio_rerio
ENSG00000099822 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 protein_coding Homo_sapiens

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