C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cytochrome P450, family 2, subfamily D, polypeptide 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100197 CYP2D6 9606 - 22:42126499-42130906 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359033 CYP2D6-002 42126556-42130865 protein_coding
  ENST00000360124 CYP2D6-003 42126499-42129909 nonsense_mediated_decay
  ENST00000360608 CYP2D6-001 42126499-42130906 protein_coding
  ENST00000389970 CYP2D6-201 42126501-42130881 protein_coding
  ENST00000488442 CYP2D6-004 42126535-42130813 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359033ENST00000360124ENST00000360608ENST00000389970ENST00000488442
Transcript ID Adipose Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359033 N/A 0.261±0.00 N/A N/A 0.142±0.00 25.317±0.00 32.943±0.00 0.393±0.00 N/A N/A N/A 0.261±0.00
ENST00000360124 0.099±0.00 N/A N/A 0.199±0.00 N/A N/A 0.493±0.00 0.042±0.00 N/A 0.367±0.00 0.109±0.04 0.895±0.00
ENST00000360608 N/A N/A 0.456±0.00 N/A N/A 107.376±0.00 19.153±0.00 N/A N/A N/A N/A N/A
ENST00000389970 N/A N/A N/A N/A N/A 0.126±0.00 N/A N/A N/A N/A N/A N/A
ENST00000488442 N/A 0.187±0.00 N/A 0.048±0.01 0.053±0.02 N/A N/A 0.068±0.00 0.579±0.00 0.045±0.00 0.031±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004BK CIL_0004BK_0001 CGP 22:42085525-42130906
CIL_0004LO CIL_0004LO_0001 CGP 22:42126499-42343616

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004497 IDA monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005739 IDA mitochondrion
GO:0005783 TAS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0006805 TAS xenobiotic metabolic process
GO:0008144 IDA drug binding
GO:0008202 IMP steroid metabolic process
GO:0009804 IDA coumarin metabolic process
GO:0009820 IDA alkaloid metabolic process
GO:0009822 IDA alkaloid catabolic process
GO:0016098 IDA monoterpenoid metabolic process
GO:0016491 IDA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 IMP drug metabolic process
GO:0020037 IDA:IEA heme binding
GO:0033076 IDA isoquinoline alkaloid metabolic process
GO:0042737 IDA drug catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0046483 IDA heterocycle metabolic process
GO:0051100 IDA negative regulation of binding
GO:0055114 IDA:IEA oxidation-reduction process
GO:0070330 IEA aromatase activity
GO:0070989 IDA oxidative demethylation
GO:0090350 IDA negative regulation of cellular organofluorine metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000022445 Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 protein_coding Mus_musculus
ENSMUSG00000061740 Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 protein_coding Mus_musculus
ENSMUSG00000068083 Cyp2d40 cytochrome P450, family 2, subfamily d, polypeptide 40 protein_coding Mus_musculus
ENSMUSG00000068085 Cyp2d11 cytochrome P450, family 2, subfamily d, polypeptide 11 protein_coding Mus_musculus
ENSMUSG00000068086 Cyp2d9 cytochrome P450, family 2, subfamily d, polypeptide 9 protein_coding Mus_musculus
ENSMUSG00000094559 Cyp2d34 cytochrome P450, family 2, subfamily d, polypeptide 34 protein_coding Mus_musculus
ENSMUSG00000094806 Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 protein_coding Mus_musculus
ENSMUSG00000096852 Cyp2d12 cytochrome P450, family 2, subfamily d, polypeptide 12 protein_coding Mus_musculus

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