C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: son of sevenless homolog 2 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100485 SOS2 9606 - 14:50117120-50231558 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216373 SOS2-001 50117120-50231558 protein_coding
  ENST00000543680 SOS2-002 50118310-50231309 protein_coding
  ENST00000555666 SOS2-005 50199701-50231101 processed_transcript
  ENST00000555794 SOS2-003 50155892-50180654 protein_coding
  ENST00000556452 SOS2-004 50201038-50231362 nonsense_mediated_decay
  ENST00000556469 SOS2-006 50182455-50231254 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216373ENST00000543680
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216373 5.830±0.00 3.167±0.00 1.265±0.00 4.007±2.59 5.773±2.22 5.846±0.00 4.301±3.52 7.804±0.00 1.699±0.30 4.824±0.18 4.810±2.07 4.397±0.23 2.942±0.51 8.906±0.03
ENST00000543680 N/A N/A 3.255±0.00 4.095±0.00 4.532±0.00 6.300±0.00 3.398±0.00 4.009±0.00 6.040±0.00 3.871±0.00 4.611±0.00 2.529±0.81 1.514±0.00 3.116±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00016A CIL_00016A_0001 CGP 14:50108632-50231558
CIL_0005HL CIL_0005HL_0002 CGP 14:50117120-50312548

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005829 TAS cytosol
GO:0007264 TAS:IEA small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS:IEA regulation of small GTPase mediated signal transduction
GO:0051057 IEA positive regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060506 sos2 son of sevenless homolog 2 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000034801 Sos2 son of sevenless homolog 2 (Drosophila) protein_coding Mus_musculus

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