C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: son of sevenless homolog 2 (Drosophila)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000216373 SOS2-001 ENSG00000100485 9606 - 14:50117120-50231558 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216373
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216373 5.830±0.00 3.167±0.00 1.265±0.00 4.007±2.59 5.773±2.22 5.846±0.00 4.301±3.52 7.804±0.00 1.699±0.30 4.824±0.18 4.810±2.07 4.397±0.23 2.942±0.51 8.906±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00016A CIL_00016A_0001 CGP 14:50108632-50231558
CIL_0005HL CIL_0005HL_0002 CGP 14:50117120-50312548

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005829 TAS cytosol
GO:0007264 TAS:IEA small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS:IEA regulation of small GTPase mediated signal transduction
GO:0051057 IEA positive regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000183277 Sos2-007 protein_coding Mus_musculus 0 5129
ENSMUST00000035773 Sos2-001 protein_coding Mus_musculus 0 5116
ENSMUST00000182396 Sos2-006 protein_coding Mus_musculus 0 3482
ENSMUST00000182123 Sos2-002 retained_intron Mus_musculus 0 813
ENSMUST00000183306 Sos2-003 retained_intron Mus_musculus 0 529
ENSMUST00000182646 Sos2-004 retained_intron Mus_musculus 0 505
ENSMUST00000182838 Sos2-005 retained_intron Mus_musculus 0 222

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