C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, ATPase, 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100764 PSMC1 9606 + 14:90256495-90275429 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261303 PSMC1-001 90256495-90275429 protein_coding
  ENST00000543772 PSMC1-002 90256578-90272550 protein_coding
  ENST00000553835 PSMC1-004 90256527-90268274 protein_coding
  ENST00000554624 PSMC1-005 90256528-90263670 retained_intron
  ENST00000555679 PSMC1-006 90256554-90263944 retained_intron
  ENST00000555787 PSMC1-003 90267476-90272624 retained_intron
  ENST00000557357 PSMC1-007 90256554-90263927 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000543772ENST00000553835ENST00000555679
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000543772 11.282±0.00 19.379±0.00 1.930±0.00 8.808±4.09 8.750±1.15 7.704±1.30 5.430±2.80 7.145±2.28 7.277±2.15 6.259±2.41 14.133±9.42 14.957±9.04 36.933±12.11 29.809±16.37
ENST00000553835 N/A N/A N/A N/A N/A N/A 16.992±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000555679 20.311±0.00 N/A 3.147±0.00 12.718±2.09 12.911±4.30 9.326±1.66 7.836±2.58 8.486±0.00 11.940±0.00 9.943±0.00 13.085±8.42 17.618±8.40 34.280±19.47 36.976±18.94

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002L5 CIL_0002L5_0002 CGP 14:90061765-90275429
CIL_0001JW CIL_0001JW_0001 CGP 14:90256495-90332137

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005838 IEA proteasome regulatory particle
GO:0006200 ISS ATP catabolic process
GO:0006281 IEA DNA repair
GO:0006310 IEA DNA recombination
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0009378 IEA four-way junction helicase activity
GO:0010467 TAS gene expression
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016787 IEA hydrolase activity
GO:0016887 ISS ATPase activity
GO:0017025 IEA TBP-class protein binding
GO:0022624 ISS proteasome accessory complex
GO:0030163 IEA protein catabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030537 psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a protein_coding Danio_rerio
ENSDARG00000043561 psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b protein_coding Danio_rerio
ENSMUSG00000021178 Psmc1 protease (prosome, macropain) 26S subunit, ATPase 1 protein_coding Mus_musculus

Loading