C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, beta type, 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100804 PSMB5 9606 - 14:23016543-23035230 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000334454 PSMB5-006 23026297-23034885 nonsense_mediated_decay
  ENST00000361611 PSMB5-002 23025851-23035145 protein_coding
  ENST00000425762 PSMB5-005 23025902-23035230 protein_coding
  ENST00000460922 PSMB5-001 23025858-23034894 protein_coding
  ENST00000493471 PSMB5-004 23025858-23034890 protein_coding
  ENST00000555895 PSMB5-007 23016543-23034727 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000334454ENST00000361611ENST00000425762ENST00000460922ENST00000493471
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000334454 21.112±0.00 16.400±0.00 N/A 33.799±0.00 28.655±0.00 18.948±0.00 21.852±0.00 26.260±0.00 14.276±0.00 22.463±0.00 22.363±0.00 35.626±0.00 41.071±0.00 37.217±7.01
ENST00000361611 N/A N/A 4.889±0.00 28.405±0.00 9.020±0.00 8.135±0.00 8.234±0.00 10.858±0.00 10.409±0.00 7.097±0.00 28.275±0.00 33.626±21.01 50.394±14.60 N/A
ENST00000425762 N/A 9.270±0.00 2.534±0.00 17.563±0.00 4.889±0.00 7.453±2.03 3.978±0.00 5.520±0.00 14.844±0.00 1.738±0.00 25.036±5.19 20.309±8.60 34.580±7.89 19.060±0.00
ENST00000460922 24.472±0.00 28.851±0.00 N/A 47.495±0.00 37.986±0.00 32.385±0.00 27.268±0.00 44.165±0.00 18.192±0.00 29.190±0.00 29.179±0.00 18.566±0.00 15.426±0.00 50.351±0.00
ENST00000493471 12.355±0.00 16.810±0.00 N/A 19.382±0.00 20.118±0.00 15.762±0.00 20.134±0.00 16.153±12.37 29.443±0.00 13.294±0.00 30.558±0.00 2.266±0.00 18.100±1.64 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006ND CIL_0006ND_0001 CGP 14:22985908-23035230
CIL_0006NC CIL_0006NC_0001 CGP 14:23016543-23044276

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005839 ISS:IEA proteasome core complex
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006979 IEA response to oxidative stress
GO:0008233 IEA peptidase activity
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0043161 IEA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075445 psmb5 proteasome (prosome, macropain) subunit, beta type, 5 protein_coding Danio_rerio
ENSMUSG00000022193 Psmb5 proteasome (prosome, macropain) subunit, beta type 5 protein_coding Mus_musculus

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