C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chromodomain helicase DNA binding protein 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100888 CHD8 9606 - 14:21385194-21456126 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000399982 CHD8-201 21385195-21431708 protein_coding
  ENST00000430710 CHD8-001 21385194-21437243 protein_coding
  ENST00000553283 CHD8-007 21429137-21437244 protein_coding
  ENST00000553622 CHD8-003 21431115-21437265 protein_coding
  ENST00000553651 CHD8-006 21431738-21437298 processed_transcript
  ENST00000553870 CHD8-012 21386011-21392788 protein_coding
  ENST00000554384 CHD8-010 21408323-21413006 retained_intron
  ENST00000555301 CHD8-011 21393671-21395014 retained_intron
  ENST00000555935 CHD8-004 21399606-21409890 protein_coding
  ENST00000555962 CHD8-008 21395024-21437230 processed_transcript
  ENST00000556833 CHD8-013 21431733-21456126 processed_transcript
  ENST00000557329 CHD8-009 21394109-21394767 retained_intron
  ENST00000557364 CHD8-002 21385486-21456080 protein_coding
  ENST00000557727 CHD8-005 21385199-21386344 retained_intron

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000399982ENST00000430710ENST00000553870ENST00000557364ENST00000557727
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000399982 2.598±0.00 1.386±0.00 N/A 1.400±0.72 0.831±0.00 1.002±0.00 1.981±0.00 2.504±0.00 0.846±0.31 1.411±0.14 3.066±0.00 1.865±0.59 1.294±0.11 3.174±0.00
ENST00000430710 4.125±0.00 3.774±0.00 N/A 4.993±0.00 2.658±0.01 1.662±0.81 0.727±0.19 1.366±0.00 1.282±0.49 1.554±0.00 N/A 3.316±2.20 2.469±1.71 6.679±1.68
ENST00000553870 N/A 16.504±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000557364 N/A N/A 1.261±0.00 3.207±0.00 2.416±1.42 1.711±0.00 N/A 1.650±0.00 1.500±0.99 4.046±0.00 1.392±0.44 2.561±1.18 0.949±0.21 4.418±0.00
ENST00000557727 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.447±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078L CIL_00078L_0001 CGP 14:21351472-21456126
CIL_0003JD CIL_0003JD_0001 CGP 14:21385194-21476973

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0002039 ISS p53 binding
GO:0003676 IEA nucleic acid binding
GO:0003677 IMP:IEA DNA binding
GO:0003678 IMP DNA helicase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0006200 IDA ATP catabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0008013 IDA beta-catenin binding
GO:0008094 IDA DNA-dependent ATPase activity
GO:0016787 IEA hydrolase activity
GO:0016817 IEA hydrolase activity, acting on acid anhydrides
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0032508 IMP DNA duplex unwinding
GO:0035064 IDA methylated histone binding
GO:0042393 ISS histone binding
GO:0043044 IMP ATP-dependent chromatin remodeling
GO:0043066 IEA negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0045945 IMP positive regulation of transcription from RNA polymerase III promoter
GO:0060070 IDA canonical Wnt signaling pathway
GO:0070016 IEA armadillo repeat domain binding
GO:0071339 IDA MLL1 complex
GO:2000270 IEA negative regulation of fibroblast apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075543 chd8 chromodomain helicase DNA binding protein 8 protein_coding Danio_rerio
ENSMUSG00000053754 Chd8 chromodomain helicase DNA binding protein 8 protein_coding Mus_musculus

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