C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: TIMP metallopeptidase inhibitor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102265 TIMP1 9606 + X:47582313-47586789 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000218388 TIMP1-001 47582313-47586789 protein_coding
  ENST00000377017 TIMP1-003 47582450-47586789 protein_coding
  ENST00000441738 TIMP1-004 47582509-47585254 protein_coding
  ENST00000445623 TIMP1-005 47585342-47586789 protein_coding
  ENST00000456754 TIMP1-002 47582408-47586023 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000218388ENST00000377017ENST00000441738
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000218388 94.243±0.00 340.355±0.00 1.310±0.00 10.945±10.14 33.576±16.07 94.976±91.39 44.972±42.89 37.835±32.01 217.627±212.49 455.120±449.60 29.015±0.00 231.537±283.96 288.974±235.16 194.961±162.18
ENST00000377017 N/A 339.942±0.00 N/A N/A 27.915±0.00 N/A N/A 70.244±64.14 76.538±0.00 N/A 2.703±0.00 11.485±0.67 139.313±0.00 80.033±71.63
ENST00000441738 N/A N/A 1.881±0.00 N/A 15.267±0.00 1.559±0.00 N/A N/A 3.883±0.00 N/A 4.473±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005GC CIL_0005GC_0001 CGP X:47561100-47619853
CIL_0006I4 CIL_0006I4_0001 CGP X:47571898-47619853
CIL_0006IH CIL_0006IH_0001 CGP X:47582313-47630305

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001775 IEA cell activation
GO:0002020 IEA protease binding
GO:0002576 TAS platelet degranulation
GO:0005125 IDA cytokine activity
GO:0005515 IPI:IEA protein binding
GO:0005576 NAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005604 IEA basement membrane
GO:0005615 IDA extracellular space
GO:0007568 IEA aging
GO:0007596 TAS blood coagulation
GO:0008083 IEA growth factor activity
GO:0008191 IEA:IDA metalloendopeptidase inhibitor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0010951 IEA:IDA negative regulation of endopeptidase activity
GO:0022617 TAS extracellular matrix disassembly
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0031012 IEA extracellular matrix
GO:0031093 TAS platelet alpha granule lumen
GO:0034097 IEA response to cytokine
GO:0042060 IEA wound healing
GO:0043066 IEA negative regulation of apoptotic process
GO:0043434 IEA response to peptide hormone
GO:0046872 IEA metal ion binding
GO:0048553 IDA negative regulation of metalloenzyme activity
GO:0051045 IDA negative regulation of membrane protein ectodomain proteolysis
GO:0070062 IDA extracellular vesicular exosome
GO:1901164 IMP negative regulation of trophoblast cell migration
GO:2001044 IMP regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000001131 Timp1 tissue inhibitor of metalloproteinase 1 protein_coding Mus_musculus

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