C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tissue inhibitor of metalloproteinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000001131 Timp1 10090 + X:20870166-20874735 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000009530 Timp1-001 20870221-20874735 protein_coding
  ENSMUST00000115342 Timp1-002 20870166-20874733 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000009530ENSMUST00000115342
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000009530 3.614±1.73 7.404±0.73 3.648±0.33 0.796±0.04 3.068±0.34 1.794±0.84 1.602±0.69 0.314±0.14 0.504±0.29 2.925±0.17 0.442±0.24 78.889±20.50 6.997±3.67 0.632±0.20
ENSMUST00000115342 5.276±2.02 14.104±3.03 5.193±1.04 0.820±0.14 6.034±0.49 3.054±0.64 3.141±0.63 0.659±0.27 0.624±0.39 5.099±1.15 0.420±0.09 88.298±45.23 7.251±3.99 0.727±0.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005GC CIL_0005GC_0002 CGP X:20797814-20921004
CIL_0006I4 CIL_0006I4_0002 CGP X:20860511-20921004
CIL_0006IH CIL_0006IH_0002 CGP X:20870166-20931555

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001775 IEA cell activation
GO:0002020 IEA protease binding
GO:0005125 ISS cytokine activity
GO:0005578 IDA proteinaceous extracellular matrix
GO:0005604 IDA basement membrane
GO:0005615 ISS extracellular space
GO:0007568 IEA aging
GO:0008083 IEA growth factor activity
GO:0008191 ISS metalloendopeptidase inhibitor activity
GO:0008284 ISS positive regulation of cell proliferation
GO:0010033 IEA response to organic substance
GO:0010951 ISS negative regulation of endopeptidase activity
GO:0031012 IEA extracellular matrix
GO:0034097 IEA response to cytokine
GO:0042060 IEA wound healing
GO:0043066 IEA negative regulation of apoptotic process
GO:0043434 IEA response to peptide hormone
GO:0046872 IEA metal ion binding
GO:0048553 ISS negative regulation of metalloenzyme activity
GO:0051045 IEA negative regulation of membrane protein ectodomain proteolysis
GO:0070062 IEA extracellular vesicular exosome
GO:1901164 IEA negative regulation of trophoblast cell migration
GO:2001044 ISS regulation of integrin-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000102265 TIMP1 TIMP metallopeptidase inhibitor 1 protein_coding Homo_sapiens

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