C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein phosphatase 2, regulatory subunit A, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105568 PPP2R1A 9606 + 19:52190039-52229533 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000322088 PPP2R1A-001 52190039-52229533 protein_coding
  ENST00000391791 PPP2R1A-012 52220983-52226401 protein_coding
  ENST00000454220 PPP2R1A-004 52190051-52216602 protein_coding
  ENST00000462047 PPP2R1A-010 52212492-52215841 retained_intron
  ENST00000462990 PPP2R1A-003 52201093-52226417 protein_coding
  ENST00000468280 PPP2R1A-009 52190114-52211694 retained_intron
  ENST00000473455 PPP2R1A-008 52201767-52212698 processed_transcript
  ENST00000473820 PPP2R1A-011 52212830-52219734 retained_intron
  ENST00000477989 PPP2R1A-005 52190091-52191404 protein_coding
  ENST00000490868 PPP2R1A-006 52190048-52211483 nonsense_mediated_decay
  ENST00000495876 PPP2R1A-007 52201181-52211296 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000322088ENST00000391791ENST00000454220ENST00000462047ENST00000462990ENST00000473455ENST00000473820
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000322088 N/A N/A 0.722±0.00 N/A 2.148±0.00 N/A 0.954±0.00 N/A 1.058±0.00 1.664±0.00 N/A 2.046±0.00 N/A 0.923±0.00
ENST00000391791 62.115±0.00 57.839±0.00 N/A 37.426±0.00 36.566±0.00 37.544±0.00 100.637±0.00 N/A 19.493±0.00 23.206±0.00 39.323±0.00 32.573±23.34 46.951±14.14 27.487±20.36
ENST00000454220 35.576±0.00 N/A N/A N/A N/A N/A 3.901±0.00 N/A 4.052±0.00 N/A N/A N/A N/A N/A
ENST00000462047 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 28.628±0.00 N/A 20.039±0.00
ENST00000462990 8.235±0.00 N/A 3.627±0.00 15.189±0.00 5.996±0.00 6.459±0.00 6.683±0.00 3.260±0.00 4.984±0.00 4.715±0.00 14.021±0.00 28.095±30.34 N/A 8.631±0.00
ENST00000473455 N/A N/A N/A N/A N/A N/A N/A 6.458±0.00 N/A N/A N/A N/A N/A N/A
ENST00000473820 N/A N/A N/A N/A N/A N/A N/A 5.439±0.00 N/A N/A N/A N/A N/A 11.934±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000086 TAS G2/M transition of mitotic cell cycle
GO:0000159 TAS protein phosphatase type 2A complex
GO:0000184 TAS nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 NAS inactivation of MAPK activity
GO:0000278 TAS mitotic cell cycle
GO:0000775 IDA chromosome, centromeric region
GO:0003823 IPI antigen binding
GO:0004722 IEA protein serine/threonine phosphatase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 NAS nucleus
GO:0005739 NAS mitochondrion
GO:0005829 TAS cytosol
GO:0006275 NAS regulation of DNA replication
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006461 TAS protein complex assembly
GO:0006470 TAS protein dephosphorylation
GO:0006672 NAS ceramide metabolic process
GO:0006915 TAS apoptotic process
GO:0007059 IDA chromosome segregation
GO:0007084 TAS mitotic nuclear envelope reassembly
GO:0008380 NAS RNA splicing
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008601 TAS protein phosphatase type 2A regulator activity
GO:0010033 NAS response to organic substance
GO:0010467 TAS gene expression
GO:0015630 NAS microtubule cytoskeleton
GO:0016020 NAS membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019932 NAS second-messenger-mediated signaling
GO:0030111 NAS regulation of Wnt signaling pathway
GO:0030155 NAS regulation of cell adhesion
GO:0030308 NAS negative regulation of cell growth
GO:0040008 NAS regulation of growth
GO:0042518 NAS negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595 NAS regulation of cell differentiation
GO:0046982 IPI protein heterodimerization activity
GO:0070062 IDA extracellular vesicular exosome
GO:0070262 IEA peptidyl-serine dephosphorylation
GO:2001241 IEA positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000007564 Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha protein_coding Mus_musculus

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