C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nucleotide-binding oligomerization domain containing 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106100 NOD1 9606 - 7:30424527-30478784 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000222823 NOD1-001 30424527-30478780 protein_coding
  ENST00000411552 NOD1-004 30456743-30478728 protein_coding
  ENST00000413433 NOD1-006 30456743-30478636 protein_coding
  ENST00000419601 NOD1-007 30456785-30478784 protein_coding
  ENST00000419799 NOD1-005 30456743-30478742 protein_coding
  ENST00000434755 NOD1-002 30424530-30478738 nonsense_mediated_decay
  ENST00000467706 NOD1-008 30425209-30433414 retained_intron
  ENST00000489614 NOD1-003 30424534-30447977 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000222823ENST00000419601ENST00000419799ENST00000434755ENST00000467706ENST00000489614
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000222823 5.766±0.00 2.402±0.00 0.353±0.00 0.298±0.17 1.175±0.57 1.168±0.74 N/A 1.187±0.00 0.463±0.10 2.710±0.96 0.373±0.00 1.674±1.52 2.008±0.73 0.851±0.51
ENST00000419601 N/A N/A N/A 0.775±0.00 N/A N/A N/A N/A 1.660±0.00 N/A N/A 3.211±0.00 N/A N/A
ENST00000419799 N/A N/A N/A N/A N/A N/A N/A 0.346±0.00 N/A N/A N/A N/A N/A N/A
ENST00000434755 N/A N/A N/A N/A N/A 1.316±0.00 N/A N/A N/A 0.932±0.00 N/A N/A N/A N/A
ENST00000467706 N/A N/A N/A N/A 2.003±0.00 1.525±0.00 1.409±0.00 N/A N/A N/A 2.101±0.00 N/A N/A 0.751±0.00
ENST00000489614 N/A N/A N/A 0.212±0.00 0.611±0.00 N/A 0.343±0.00 N/A N/A 1.339±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I3 CIL_0006I3_0002 CGP 7:30284307-30478784
CIL_000408 CIL_000408_0001 CGP 7:30424527-30551479

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002606 ISS positive regulation of dendritic cell antigen processing and presentation
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006915 TAS apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 TAS defense response
GO:0006954 TAS inflammatory response
GO:0007165 TAS signal transduction
GO:0007254 TAS JNK cascade
GO:0008656 TAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009595 TAS detection of biotic stimulus
GO:0016045 IDA detection of bacterium
GO:0016323 IDA basolateral plasma membrane
GO:0032755 IEA positive regulation of interleukin-6 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 IDA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042228 IDA interleukin-8 biosynthetic process
GO:0042742 IDA defense response to bacterium
GO:0042802 IDA identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0042834 TAS peptidoglycan binding
GO:0042981 IEA regulation of apoptotic process
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 TAS innate immune response
GO:0046330 IEA positive regulation of JNK cascade
GO:0050700 IDA CARD domain binding
GO:0050830 IEA defense response to Gram-positive bacterium
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051259 TAS protein oligomerization
GO:0051403 TAS stress-activated MAPK cascade
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036308 nod1 nucleotide-binding oligomerization domain containing 1 protein_coding Danio_rerio
ENSMUSG00000038058 Nod1 nucleotide-binding oligomerization domain containing 1 protein_coding Mus_musculus

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