C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glucokinase (hexokinase 4)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106633 GCK 9606 - 7:44144271-44198170 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336642 GCK-006 44144275-44146144 protein_coding
  ENST00000345378 GCK-002 44144278-44159282 protein_coding
  ENST00000395796 GCK-003 44144277-44159275 protein_coding
  ENST00000403799 GCK-001 44144275-44189423 protein_coding
  ENST00000437084 GCK-004 44145132-44188987 protein_coding
  ENST00000459642 GCK-005 44144273-44146129 retained_intron
  ENST00000473353 GCK-007 44145644-44147125 processed_transcript
  ENST00000476008 GCK-008 44153391-44198170 processed_transcript
  ENST00000616242 GCK-201 44144271-44158114 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336642ENST00000345378ENST00000403799ENST00000437084ENST00000459642ENST00000473353ENST00000476008ENST00000616242
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336642 0.431±0.00 1.169±0.00 1.565±1.40 0.075±0.00 0.426±0.00 0.724±0.00 0.538±0.00 0.258±0.00 0.311±0.00 0.375±0.00 1.585±1.31 1.179±0.14 0.317±0.11
ENST00000345378 N/A N/A N/A N/A N/A N/A 1.630±0.00 N/A N/A N/A N/A N/A N/A
ENST00000403799 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.076±0.00
ENST00000437084 N/A N/A N/A N/A 0.235±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000459642 N/A N/A N/A N/A N/A 0.111±0.00 N/A N/A 0.130±0.00 N/A 0.836±0.31 0.649±0.00 0.260±0.00
ENST00000473353 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.311±0.00
ENST00000476008 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.053±0.00 N/A 0.133±0.00
ENST00000616242 N/A N/A 0.303±0.00 0.112±0.00 N/A 0.044±0.00 N/A 0.406±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I9 CIL_0006I9_0002 CGP 7:44138864-44198170
CIL_0000J5 CIL_0000J5_0001 CGP 7:44144271-44214294

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001678 IBA cellular glucose homeostasis
GO:0004340 IDA glucokinase activity
GO:0004396 IEA hexokinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005536 IDA glucose binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0005884 IEA actin filament
GO:0005938 IEA cell cortex
GO:0005975 IEA carbohydrate metabolic process
GO:0005978 IEA glycogen biosynthetic process
GO:0006003 IEA fructose 2,6-bisphosphate metabolic process
GO:0006006 IEA glucose metabolic process
GO:0006096 IEA glycolytic process
GO:0006110 NAS regulation of glycolytic process
GO:0006739 IEA NADP metabolic process
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0008645 TAS hexose transport
GO:0009749 IEA response to glucose
GO:0010827 TAS regulation of glucose transport
GO:0015758 TAS glucose transport
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0019903 IEA protein phosphatase binding
GO:0019932 IEA second-messenger-mediated signaling
GO:0030141 IEA secretory granule
GO:0031018 TAS endocrine pancreas development
GO:0032024 IMP positive regulation of insulin secretion
GO:0032811 IEA negative regulation of epinephrine secretion
GO:0032869 ISS cellular response to insulin stimulus
GO:0042149 IEA cellular response to glucose starvation
GO:0042327 IEA positive regulation of phosphorylation
GO:0042593 IMP glucose homeostasis
GO:0043266 IEA regulation of potassium ion transport
GO:0043531 IEA ADP binding
GO:0044281 TAS small molecule metabolic process
GO:0044320 ISS cellular response to leptin stimulus
GO:0045180 IEA basal cortex
GO:0045721 IMP negative regulation of gluconeogenesis
GO:0045725 IMP positive regulation of glycogen biosynthetic process
GO:0045821 IEA positive regulation of glycolytic process
GO:0046835 IEA carbohydrate phosphorylation
GO:0050796 IMP regulation of insulin secretion
GO:0051156 IEA glucose 6-phosphate metabolic process
GO:0051594 IMP detection of glucose
GO:0055085 TAS transmembrane transport
GO:0055088 IEA lipid homeostasis
GO:0070509 IEA calcium ion import

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068006 gck glucokinase (hexokinase 4, maturity onset diabetes of the young 2) protein_coding Danio_rerio
ENSMUSG00000041798 Gck glucokinase protein_coding Mus_musculus

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