C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glucokinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000041798 Gck 10090 - 11:5900820-5950081 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000102920 Gck-004 5900823-5950081 protein_coding
  ENSMUST00000109822 Gck-002 5900820-5915124 protein_coding
  ENSMUST00000109823 Gck-001 5900820-5915124 protein_coding
  ENSMUST00000125434 Gck-003 5901569-5902087 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000102920ENSMUST00000109822ENSMUST00000109823ENSMUST00000125434
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000102920 0.075±0.02 0.295±0.15 N/A 0.695±0.09 N/A 0.156±0.02 N/A N/A 0.023±0.01 0.390±0.10 N/A 0.668±0.35 0.015±0.00 2.690±0.48
ENSMUST00000109822 0.087±0.02 N/A N/A N/A 0.137±0.09 0.247±0.09 1.030±0.00 0.029±0.01 5.116±5.18 0.134±0.00 N/A 0.658±0.05 N/A 0.921±0.25
ENSMUST00000109823 0.013±0.00 0.749±0.60 0.024±0.01 1.072±0.00 0.261±0.09 0.247±0.12 3.630±1.06 0.081±0.03 33.110±33.99 0.293±0.20 3.569±1.49 0.724±0.47 0.149±0.18 N/A
ENSMUST00000125434 0.144±0.01 N/A N/A N/A N/A 0.507±0.00 N/A 0.255±0.00 N/A N/A N/A N/A 0.141±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I9 CIL_0006I9_0003 CGP 11:5896637-5950081
CIL_0000J5 CIL_0000J5_0002 CGP 11:5900820-5967780

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0001678 IMP cellular glucose homeostasis
GO:0004340 ISS glucokinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005536 ISS glucose binding
GO:0005634 IDA nucleus
GO:0005654 IEA nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 IBA cytosol
GO:0005884 IEA actin filament
GO:0005938 IEA cell cortex
GO:0005978 IEA glycogen biosynthetic process
GO:0006003 IEA fructose 2,6-bisphosphate metabolic process
GO:0006006 IDA glucose metabolic process
GO:0006096 IBA glycolytic process
GO:0006739 IMP NADP metabolic process
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0009749 IEA response to glucose
GO:0019903 IEA protein phosphatase binding
GO:0019932 IEA second-messenger-mediated signaling
GO:0030141 IEA secretory granule
GO:0031018 TAS endocrine pancreas development
GO:0032024 ISS positive regulation of insulin secretion
GO:0032811 IEA negative regulation of epinephrine secretion
GO:0032869 IEA cellular response to insulin stimulus
GO:0042149 IEA cellular response to glucose starvation
GO:0042327 IEA positive regulation of phosphorylation
GO:0042593 ISS glucose homeostasis
GO:0043266 IMP regulation of potassium ion transport
GO:0043531 IEA ADP binding
GO:0044320 IEA cellular response to leptin stimulus
GO:0045180 IEA basal cortex
GO:0045721 ISS negative regulation of gluconeogenesis
GO:0045725 ISS positive regulation of glycogen biosynthetic process
GO:0045821 IEA positive regulation of glycolytic process
GO:0046835 IDA carbohydrate phosphorylation
GO:0050796 IMP regulation of insulin secretion
GO:0051156 IEA glucose 6-phosphate metabolic process
GO:0051594 ISS detection of glucose
GO:0055088 IEA lipid homeostasis
GO:0070509 IMP calcium ion import

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068006 gck glucokinase (hexokinase 4, maturity onset diabetes of the young 2) protein_coding Danio_rerio
ENSG00000106633 GCK glucokinase (hexokinase 4) protein_coding Homo_sapiens

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