C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106799 TGFBR1 9606 + 9:99104038-99154192 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374990 TGFBR1-003 99105111-99153649 protein_coding
  ENST00000374994 TGFBR1-001 99105089-99154192 protein_coding
  ENST00000546584 TGFBR1-012 99127934-99132739 protein_coding
  ENST00000547314 TGFBR1-008 99104038-99132726 protein_coding
  ENST00000548365 TGFBR1-011 99127874-99132703 protein_coding
  ENST00000549021 TGFBR1-010 99127775-99138064 protein_coding
  ENST00000549766 TGFBR1-005 99105150-99149528 nonsense_mediated_decay
  ENST00000550253 TGFBR1-007 99127916-99149341 protein_coding
  ENST00000552516 TGFBR1-004 99105150-99153658 protein_coding
  ENST00000552573 TGFBR1-009 99104070-99132739 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374990ENST00000374994ENST00000549021ENST00000550253ENST00000552516
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374990 3.325±0.00 1.455±0.00 N/A 3.192±0.00 2.625±0.00 0.778±0.00 0.967±0.00 2.642±0.00 0.784±0.00 1.300±0.00 0.683±0.00 1.168±0.00 0.826±0.00 1.904±0.00
ENST00000374994 N/A 0.805±0.00 N/A 2.004±0.00 0.894±0.00 1.446±0.00 0.970±0.00 0.852±0.04 2.199±0.00 1.181±0.18 0.765±0.48 2.809±1.78 2.905±0.72 0.901±0.00
ENST00000549021 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.581±0.00
ENST00000550253 N/A N/A N/A N/A 5.413±0.00 N/A N/A N/A N/A N/A N/A 4.057±0.00 N/A 6.219±0.00
ENST00000552516 1.077±0.00 0.695±0.00 1.734±0.00 1.467±0.16 2.726±1.70 2.022±0.00 1.239±0.28 1.275±0.00 3.123±2.01 6.001±1.52 1.709±0.00 2.161±1.18 7.621±7.24 4.952±0.53

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007BK CIL_0007BK_0002 CGP 9:98943179-99154192
CIL_0001ZZ CIL_0001ZZ_0001 CGP 9:99104038-99221956

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IDA activation of MAPKK activity
GO:0001501 ISS skeletal system development
GO:0001525 IEA angiogenesis
GO:0001701 ISS in utero embryonic development
GO:0001822 ISS kidney development
GO:0001824 IEA blastocyst development
GO:0001837 IDA epithelial to mesenchymal transition
GO:0001937 IEA negative regulation of endothelial cell proliferation
GO:0002088 IEA lens development in camera-type eye
GO:0004514 IEA nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004675 IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA:IDA transforming growth factor beta-activated receptor activity
GO:0005025 IDA transforming growth factor beta receptor activity, type I
GO:0005114 IDA type II transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005768 IEA endosome
GO:0005886 IDA plasma membrane
GO:0005923 IDA tight junction
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IEA:IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007050 TAS cell cycle arrest
GO:0007165 IDA signal transduction
GO:0007178 IEA transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007507 ISS heart development
GO:0008284 IMP positive regulation of cell proliferation
GO:0008354 ISS germ cell migration
GO:0008584 IEA male gonad development
GO:0009435 IEA NAD biosynthetic process
GO:0009791 IEA post-embryonic development
GO:0009952 ISS anterior/posterior pattern specification
GO:0010468 IEA regulation of gene expression
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019838 IPI growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030199 ISS collagen fibril organization
GO:0030307 IDA positive regulation of cell growth
GO:0030512 TAS negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396 IDA regulation of protein ubiquitination
GO:0032331 ISS negative regulation of chondrocyte differentiation
GO:0042060 TAS wound healing
GO:0043062 TAS extracellular structure organization
GO:0043066 IEA negative regulation of apoptotic process
GO:0043235 IDA receptor complex
GO:0043393 IEA regulation of protein binding
GO:0043542 IEA endothelial cell migration
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048538 ISS thymus development
GO:0048663 ISS neuron fate commitment
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048705 ISS skeletal system morphogenesis
GO:0048762 TAS mesenchymal cell differentiation
GO:0048844 ISS artery morphogenesis
GO:0048870 IMP cell motility
GO:0050431 IDA transforming growth factor beta binding
GO:0051272 IMP positive regulation of cellular component movement
GO:0051491 IEA positive regulation of filopodium assembly
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060017 ISS parathyroid gland development
GO:0060021 ISS palate development
GO:0060037 ISS pharyngeal system development
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060391 IDA positive regulation of SMAD protein import into nucleus
GO:0070022 IC transforming growth factor beta receptor homodimeric complex
GO:0070411 IPI I-SMAD binding
GO:0070723 IDA response to cholesterol
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:2001235 IDA positive regulation of apoptotic signaling pathway
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017494 tgfbr1a transforming growth factor, beta receptor 1 a protein_coding Danio_rerio
ENSDARG00000042259 tgfbr1b transforming growth factor, beta receptor 1 b protein_coding Danio_rerio
ENSMUSG00000007613 Tgfbr1 transforming growth factor, beta receptor I protein_coding Mus_musculus

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