C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transforming growth factor, beta receptor I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000007613 Tgfbr1 10090 + 4:47353222-47414931 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000007757 Tgfbr1-001 47353222-47414931 protein_coding
  ENSMUST00000044234 Tgfbr1-003 47353307-47412133 protein_coding
  ENSMUST00000107725 Tgfbr1-002 47386216-47411035 protein_coding
  ENSMUST00000123962 Tgfbr1-005 47353598-47361313 processed_transcript
  ENSMUST00000126171 Tgfbr1-004 47353610-47410807 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000007757ENSMUST00000107725ENSMUST00000126171
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000007757 4.061±2.00 4.609±1.40 8.156±2.67 7.897±5.47 2.788±1.02 2.756±0.71 0.976±0.38 3.666±0.63 2.099±1.07 4.610±1.52 2.321±0.64 9.465±3.73 4.849±3.78 2.266±1.13
ENSMUST00000107725 N/A N/A N/A 1.717±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.851±3.13
ENSMUST00000126171 N/A N/A N/A N/A N/A 1.606±0.00 N/A N/A N/A N/A N/A N/A N/A 6.069±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007BK CIL_0007BK_0003 CGP 4:47208161-47414931
CIL_0001ZZ CIL_0001ZZ_0002 CGP 4:47353222-47474333

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0001501 IGI skeletal system development
GO:0001525 IMP angiogenesis
GO:0001701 IMP in utero embryonic development
GO:0001822 IGI kidney development
GO:0001824 IDA blastocyst development
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001937 IGI negative regulation of endothelial cell proliferation
GO:0002088 IMP lens development in camera-type eye
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005024 IDA transforming growth factor beta-activated receptor activity
GO:0005025 IEA transforming growth factor beta receptor activity, type I
GO:0005114 IEA type II transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005768 IDA endosome
GO:0005886 IEA plasma membrane
GO:0005901 ISO caveola
GO:0005923 IEA tight junction
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 IEA signal transduction
GO:0007179 IMP transforming growth factor beta receptor signaling pathway
GO:0007507 IMP heart development
GO:0008284 IEA positive regulation of cell proliferation
GO:0008354 IMP germ cell migration
GO:0008584 IMP male gonad development
GO:0009791 IMP post-embryonic development
GO:0009952 IGI anterior/posterior pattern specification
GO:0010468 IMP regulation of gene expression
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016021 IEA integral component of membrane
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019838 IEA growth factor binding
GO:0023014 IEA signal transduction by phosphorylation
GO:0030199 IMP collagen fibril organization
GO:0030307 IEA positive regulation of cell growth
GO:0031396 IEA regulation of protein ubiquitination
GO:0032331 IMP negative regulation of chondrocyte differentiation
GO:0043066 IMP negative regulation of apoptotic process
GO:0043235 IEA receptor complex
GO:0043393 IMP regulation of protein binding
GO:0043542 IMP endothelial cell migration
GO:0045121 ISO membrane raft
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048538 IMP thymus development
GO:0048663 IMP neuron fate commitment
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048705 IGI skeletal system morphogenesis
GO:0048844 IMP artery morphogenesis
GO:0048870 IEA cell motility
GO:0050431 IPI transforming growth factor beta binding
GO:0051272 IEA positive regulation of cellular component movement
GO:0051491 IMP positive regulation of filopodium assembly
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060017 IMP parathyroid gland development
GO:0060021 IMP palate development
GO:0060037 IMP pharyngeal system development
GO:0060389 IEA pathway-restricted SMAD protein phosphorylation
GO:0060391 IEA positive regulation of SMAD protein import into nucleus
GO:0070411 IEA I-SMAD binding
GO:0070723 IDA response to cholesterol
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:2001235 IEA positive regulation of apoptotic signaling pathway
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017494 tgfbr1a transforming growth factor, beta receptor 1 a protein_coding Danio_rerio
ENSDARG00000042259 tgfbr1b transforming growth factor, beta receptor 1 b protein_coding Danio_rerio
ENSG00000106799 TGFBR1 transforming growth factor, beta receptor 1 protein_coding Homo_sapiens

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