C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108443 RPS6KB1 9606 + 17:59893046-59950564 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000225577 RPS6KB1-001 59893164-59950564 protein_coding
  ENST00000393021 RPS6KB1-201 59893046-59950421 protein_coding
  ENST00000406116 RPS6KB1-002 59893145-59948188 protein_coding
  ENST00000443572 RPS6KB1-008 59893130-59947137 protein_coding
  ENST00000472940 RPS6KB1-003 59893086-59947461 nonsense_mediated_decay
  ENST00000475155 RPS6KB1-006 59945191-59946941 retained_intron
  ENST00000477179 RPS6KB1-005 59893126-59913805 processed_transcript
  ENST00000489824 RPS6KB1-004 59893138-59931692 nonsense_mediated_decay
  ENST00000587061 RPS6KB1-011 59947578-59950420 processed_transcript
  ENST00000587622 RPS6KB1-009 59931320-59934522 retained_intron
  ENST00000590928 RPS6KB1-010 59934145-59935037 retained_intron
  ENST00000592726 RPS6KB1-007 59906988-59914668 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000225577ENST00000393021ENST00000406116ENST00000443572ENST00000475155
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000225577 N/A N/A N/A 1.397±0.00 2.746±0.00 2.359±0.00 0.475±0.00 N/A 2.908±0.00 N/A 1.125±0.00 2.667±0.78 1.547±0.48 N/A
ENST00000393021 4.040±0.00 3.780±0.00 N/A 2.532±1.82 4.738±0.00 2.287±0.00 2.056±1.24 2.862±0.00 2.032±0.00 3.437±0.41 5.424±0.00 2.399±0.73 1.103±0.10 3.585±0.00
ENST00000406116 N/A N/A 1.119±0.00 N/A N/A N/A N/A N/A N/A N/A 1.658±0.00 N/A N/A N/A
ENST00000443572 N/A N/A 1.711±0.00 1.794±0.00 2.137±0.00 N/A N/A 1.787±0.00 N/A 2.893±0.00 1.194±0.00 N/A 2.352±0.23 N/A
ENST00000475155 N/A N/A N/A N/A N/A 9.558±0.00 N/A 6.231±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081F CIL_00081F_0001 VISTA 17:59485788-60087415
CIL_0008Y2 CIL_0008Y2_0001 VISTA 17:59536739-60138754
CIL_0008VS CIL_0008VS_0001 VISTA 17:59556856-60159441
CIL_00056A CIL_00056A_0002 CGP 17:59859482-59950564

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0003009 IEA skeletal muscle contraction
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004711 IEA ribosomal protein S6 kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005741 IEA mitochondrial outer membrane
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007165 TAS:IEA signal transduction
GO:0007281 IEA germ cell development
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0007616 IEA long-term memory
GO:0008286 TAS insulin receptor signaling pathway
GO:0009408 IEA response to heat
GO:0009611 IEA response to wounding
GO:0009612 IEA response to mechanical stimulus
GO:0009636 IEA response to toxic substance
GO:0009749 IEA response to glucose
GO:0009986 IEA cell surface
GO:0010033 IEA response to organic substance
GO:0014070 IEA response to organic cyclic compound
GO:0014732 IEA skeletal muscle atrophy
GO:0014878 IEA response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911 IEA positive regulation of smooth muscle cell migration
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030054 IEA cell junction
GO:0031929 IDA TOR signaling
GO:0032496 IEA response to lipopolysaccharide
GO:0032868 IEA response to insulin
GO:0032870 IEA cellular response to hormone stimulus
GO:0033574 IEA response to testosterone
GO:0033762 IEA response to glucagon
GO:0034612 IEA response to tumor necrosis factor
GO:0042277 IEA peptide binding
GO:0042493 IEA response to drug
GO:0043005 IEA neuron projection
GO:0043066 IMP negative regulation of apoptotic process
GO:0043200 IEA response to amino acid
GO:0043201 IEA response to leucine
GO:0043434 IEA response to peptide hormone
GO:0043491 IEA protein kinase B signaling
GO:0045202 IEA synapse
GO:0045471 IEA response to ethanol
GO:0045727 IMP positive regulation of translation
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0045948 IMP positive regulation of translational initiation
GO:0046324 IEA regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048633 IEA positive regulation of skeletal muscle tissue growth
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051384 IEA response to glucocorticoid
GO:0071363 IDA cellular response to growth factor stimulus
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058230 rps6kb1b ribosomal protein S6 kinase b, polypeptide 1b protein_coding Danio_rerio
ENSMUSG00000020516 Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 protein_coding Mus_musculus

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