C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DEXH (Asp-Glu-X-His) box polypeptide 58
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108771 DHX58 9606 - 17:42101404-42112733 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251642 DHX58-001 42101404-42112733 protein_coding
  ENST00000413196 DHX58-002 42107693-42112486 protein_coding
  ENST00000430773 DHX58-003 42110816-42112463 protein_coding
  ENST00000586522 DHX58-006 42103213-42112713 retained_intron
  ENST00000589979 DHX58-012 42101404-42104907 nonsense_mediated_decay
  ENST00000590637 DHX58-010 42103608-42107848 retained_intron
  ENST00000591220 DHX58-009 42110779-42112714 protein_coding
  ENST00000592024 DHX58-011 42101600-42102809 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000251642ENST00000413196ENST00000586522ENST00000589979ENST00000590637ENST00000591220ENST00000592024
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000251642 3.193±0.00 3.223±0.00 N/A 1.193±0.00 1.758±0.00 N/A 0.681±0.00 2.093±0.00 0.251±0.00 3.044±0.00 N/A 2.427±0.57 3.418±0.37 2.832±0.37
ENST00000413196 N/A N/A N/A N/A N/A N/A 0.201±0.00 N/A N/A 0.629±0.00 N/A 2.298±1.55 2.469±0.00 7.048±0.00
ENST00000586522 N/A 1.074±0.00 N/A N/A N/A N/A N/A N/A N/A 0.392±0.00 N/A N/A N/A N/A
ENST00000589979 N/A N/A N/A 1.879±0.00 3.245±0.00 N/A N/A N/A 2.993±0.00 4.145±0.00 0.678±0.27 N/A N/A N/A
ENST00000590637 N/A N/A 0.358±0.00 N/A 0.906±0.00 0.642±0.00 N/A 1.242±0.00 N/A N/A N/A 1.761±0.00 N/A N/A
ENST00000591220 N/A N/A N/A N/A N/A N/A N/A 3.158±0.00 N/A N/A 1.854±0.00 N/A N/A N/A
ENST00000592024 N/A 4.650±0.00 0.185±0.00 2.264±0.00 N/A 1.099±0.00 N/A 1.543±0.00 0.811±0.00 2.372±0.00 N/A 3.847±0.00 N/A 3.354±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00003J CIL_00003J_0001 CGP 17:42025576-42112733
CIL_0004GH CIL_0004GH_0001 CGP 17:42101404-42121358

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003677 IEA DNA binding
GO:0003725 IDA double-stranded RNA binding
GO:0003727 IDA single-stranded RNA binding
GO:0004386 IEA helicase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0008152 IEA metabolic process
GO:0008270 IDA zinc ion binding
GO:0009615 ISS response to virus
GO:0016032 IEA viral process
GO:0016787 IEA hydrolase activity
GO:0016817 IEA hydrolase activity, acting on acid anhydrides
GO:0032480 IDA negative regulation of type I interferon production
GO:0032481 ISS positive regulation of type I interferon production
GO:0039534 IMP negative regulation of MDA-5 signaling pathway
GO:0039536 IDA negative regulation of RIG-I signaling pathway
GO:0045087 IEA innate immune response
GO:0045088 IDA regulation of innate immune response
GO:0045824 IDA negative regulation of innate immune response
GO:0051607 IEA defense response to virus
GO:1900245 ISS positive regulation of MDA-5 signaling pathway
GO:1900246 ISS positive regulation of RIG-I signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089463 dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 protein_coding Danio_rerio
ENSMUSG00000017830 Dhx58 DEXH (Asp-Glu-X-His) box polypeptide 58 protein_coding Mus_musculus

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