C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD specific E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018363 Smurf2 10090 - 11:106820066-106920715 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000092517 Smurf2-002 106822025-106920470 protein_coding
  ENSMUST00000103067 Smurf2-001 106820066-106920715 protein_coding
  ENSMUST00000130688 Smurf2-005 106824718-106829006 processed_transcript
  ENSMUST00000139297 Smurf2-003 106822025-106920275 processed_transcript
  ENSMUST00000144027 Smurf2-004 106830588-106839298 processed_transcript
  ENSMUST00000167787 Smurf2-201 106822613-106920359 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000092517ENSMUST00000103067ENSMUST00000139297ENSMUST00000167787
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000092517 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.460±0.00 N/A
ENSMUST00000103067 6.740±1.39 2.532±1.88 4.968±2.40 6.548±3.83 2.013±0.86 2.855±1.50 2.970±0.00 3.319±1.07 15.325±0.00 2.936±1.16 4.619±1.62 4.636±1.84 3.417±2.41
ENSMUST00000139297 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.167±0.00 N/A N/A
ENSMUST00000167787 N/A N/A N/A 6.596±0.00 2.270±0.00 N/A N/A N/A N/A N/A 7.370±4.54 12.875±0.54 13.593±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006GQ CIL_0006GQ_0002 CGP 11:106789252-106920715
CIL_0001XS CIL_0001XS_0002 CGP 11:106820066-106999541

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 IEA ubiquitin ligase complex
GO:0004842 IBA ubiquitin-protein transferase activity
GO:0005160 IEA transforming growth factor beta receptor binding
GO:0005515 IPI protein binding
GO:0005634 IBA nucleus
GO:0005737 IBA cytoplasm
GO:0005886 IEA plasma membrane
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0007179 IBA transforming growth factor beta receptor signaling pathway
GO:0016874 IEA ligase activity
GO:0030579 IEA ubiquitin-dependent SMAD protein catabolic process
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IEA identical protein binding
GO:0046332 IEA SMAD binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038067 smurf2 SMAD specific E3 ubiquitin protein ligase 2 protein_coding Danio_rerio
ENSG00000108854 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 protein_coding Homo_sapiens

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