C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired-like homeobox 2b
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109132 PHOX2B 9606 - 4:41744082-41748970 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000226382 PHOX2B-001 41744082-41748970 protein_coding
  ENST00000510424 PHOX2B-002 41746033-41747709 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonTestisENST00000226382ENST00000510424
Transcript ID Adrenal Breast Colon Testis
ENST00000226382 0.006±0.00 0.137±0.00 0.597±0.00 0.029±0.00
ENST00000510424 N/A N/A 0.944±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028N CIL_00028N_0002 CGP 4:41359607-41748970
CIL_00038I CIL_00038I_0001 CGP 4:41744082-41960572

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001764 ISS neuron migration
GO:0002087 ISS regulation of respiratory gaseous exchange by neurological system process
GO:0003357 ISS noradrenergic neuron differentiation
GO:0003358 ISS noradrenergic neuron development
GO:0003360 IEP brainstem development
GO:0003677 IEA DNA binding
GO:0005634 IEA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0008285 IEA negative regulation of cell proliferation
GO:0010001 ISS glial cell differentiation
GO:0010468 ISS regulation of gene expression
GO:0010971 ISS positive regulation of G2/M transition of mitotic cell cycle
GO:0021533 ISS cell differentiation in hindbrain
GO:0021723 ISS medullary reticular formation development
GO:0021934 ISS hindbrain tangential cell migration
GO:0030182 IEA neuron differentiation
GO:0035914 IEA skeletal muscle cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IEA cell development
GO:0048483 IMP autonomic nervous system development
GO:0048484 IEP enteric nervous system development
GO:0048485 ISS sympathetic nervous system development
GO:0048486 ISS parasympathetic nervous system development
GO:0048839 ISS inner ear development
GO:0048894 ISS efferent axon development in a lateral line nerve
GO:0060541 ISS respiratory system development
GO:0061452 ISS retrotrapezoid nucleus neuron differentiation
GO:0061549 ISS sympathetic ganglion development
GO:0071157 ISS negative regulation of cell cycle arrest
GO:0071542 ISS dopaminergic neuron differentiation
GO:0071773 ISS cellular response to BMP stimulus
GO:1901166 ISS neural crest cell migration involved in autonomic nervous system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071751 phox2bb paired-like homeobox 2bb protein_coding Danio_rerio
ENSDARG00000091029 phox2bb paired-like homeobox 2bb protein_coding Danio_rerio
ENSMUSG00000012520 Phox2b paired-like homeobox 2b protein_coding Mus_musculus

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