C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: paired-like homeobox 2b
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000012520 Phox2b 10090 - 5:67094405-67099301 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000012664 Phox2b-001 67094405-67099301 protein_coding
  ENSMUST00000174251 Phox2b-002 67097044-67099057 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainColonHeartKidneyLiverLungPlacentaTestisENSMUST00000012664ENSMUST00000174251
Transcript ID Adipose Adrenal Bladder Brain Colon Heart Kidney Liver Lung Placenta Testis
ENSMUST00000012664 0.025±0.02 7.084±1.25 0.190±0.02 3.736±2.25 2.182±0.47 0.075±0.02 0.118±0.05 0.028±0.03 0.022±0.01 0.027±0.00 0.011±0.00
ENSMUST00000174251 N/A 6.429±2.16 N/A N/A 1.177±0.35 N/A N/A 0.011±0.01 0.019±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00028N CIL_00028N_0003 CGP 5:66745835-67099301
CIL_00038I CIL_00038I_0002 CGP 5:67094405-67291461

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001764 IMP neuron migration
GO:0002087 IMP regulation of respiratory gaseous exchange by neurological system process
GO:0003357 IMP noradrenergic neuron differentiation
GO:0003358 IMP noradrenergic neuron development
GO:0003360 IEA brainstem development
GO:0003677 IEA DNA binding
GO:0005634 IDA nucleus
GO:0008285 IMP negative regulation of cell proliferation
GO:0010001 IMP glial cell differentiation
GO:0010468 IMP regulation of gene expression
GO:0021533 IMP cell differentiation in hindbrain
GO:0021723 IEP medullary reticular formation development
GO:0021934 IMP hindbrain tangential cell migration
GO:0030182 IMP neuron differentiation
GO:0035914 IMP skeletal muscle cell differentiation
GO:0045665 IGI negative regulation of neuron differentiation
GO:0045666 IGI positive regulation of neuron differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IMP cell development
GO:0048483 IEA autonomic nervous system development
GO:0048484 IMP enteric nervous system development
GO:0048485 IMP sympathetic nervous system development
GO:0048486 IMP parasympathetic nervous system development
GO:0048839 IMP inner ear development
GO:0048894 IMP efferent axon development in a lateral line nerve
GO:0060541 IMP respiratory system development
GO:0061452 IMP retrotrapezoid nucleus neuron differentiation
GO:0061549 IMP sympathetic ganglion development
GO:0071542 IMP dopaminergic neuron differentiation
GO:0071773 IDA cellular response to BMP stimulus
GO:1901166 IMP neural crest cell migration involved in autonomic nervous system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000071751 phox2bb paired-like homeobox 2bb protein_coding Danio_rerio
ENSDARG00000091029 phox2bb paired-like homeobox 2bb protein_coding Danio_rerio
ENSG00000109132 PHOX2B paired-like homeobox 2b protein_coding Homo_sapiens

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