C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109670 FBXW7 9606 - 4:152321259-152536101 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263981 FBXW7-005 152321263-152352971 protein_coding
  ENST00000281708 FBXW7-001 152321259-152536101 protein_coding
  ENST00000296555 FBXW7-003 152321259-152382515 protein_coding
  ENST00000393956 FBXW7-007 152322819-152348806 protein_coding
  ENST00000603548 FBXW7-002 152322623-152535001 protein_coding
  ENST00000603821 FBXW7-008 152322819-152329073 retained_intron
  ENST00000603841 FBXW7-012 152322819-152411878 protein_coding
  ENST00000604069 FBXW7-010 152326222-152332767 retained_intron
  ENST00000604095 FBXW7-014 152530273-152535210 processed_transcript
  ENST00000604316 FBXW7-011 152322875-152324436 retained_intron
  ENST00000604822 FBXW7-009 152346812-152352696 retained_intron
  ENST00000604872 FBXW7-004 152411160-152535240 protein_coding
  ENST00000605042 FBXW7-013 152411329-152412606 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263981ENST00000281708ENST00000296555ENST00000603548ENST00000603821ENST00000603841ENST00000604069ENST00000605042
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263981 N/A N/A N/A 31.272±3.27 3.347±0.00 N/A N/A 1.356±0.00 N/A N/A N/A N/A N/A N/A
ENST00000281708 3.753±0.00 4.996±0.00 0.913±0.00 N/A 4.090±1.01 1.391±0.22 1.260±0.00 2.500±0.00 1.191±0.44 3.651±0.00 0.935±0.00 1.679±0.64 1.053±0.00 9.915±0.00
ENST00000296555 N/A N/A N/A N/A N/A N/A 3.146±0.52 N/A N/A N/A 2.261±0.86 N/A N/A N/A
ENST00000603548 N/A N/A N/A N/A N/A 0.967±0.00 N/A N/A N/A N/A N/A 2.305±0.76 2.758±0.00 9.445±0.00
ENST00000603821 N/A 0.860±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000603841 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.767±0.00 0.491±0.00 N/A
ENST00000604069 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.449±0.00 N/A N/A N/A
ENST00000605042 N/A N/A 15.088±0.00 52.127±0.00 36.087±0.00 23.657±0.00 15.325±0.00 21.242±0.00 38.393±0.00 50.128±0.00 4.488±0.00 19.521±10.37 6.430±0.00 19.939±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CH CIL_0008CH_0001 VISTA 4:152066503-152669365

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001570 IEA vasculogenesis
GO:0001944 TAS vasculature development
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007062 IMP sister chromatid cohesion
GO:0007219 TAS Notch signaling pathway
GO:0010868 ISS negative regulation of triglyceride biosynthetic process
GO:0010883 ISS regulation of lipid storage
GO:0016032 IEA viral process
GO:0016567 IDA protein ubiquitination
GO:0019005 IDA SCF ubiquitin ligase complex
GO:0030324 IEA lung development
GO:0030332 IDA cyclin binding
GO:0030674 IDA protein binding, bridging
GO:0031146 IDA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032876 IMP negative regulation of DNA endoreduplication
GO:0032880 ISS regulation of protein localization
GO:0034644 IDA cellular response to UV
GO:0042802 IPI identical protein binding
GO:0043234 IDA protein complex
GO:0045741 IDA positive regulation of epidermal growth factor-activated receptor activity
GO:0045746 ISS negative regulation of Notch signaling pathway
GO:0050821 IDA protein stabilization
GO:0051443 IDA positive regulation of ubiquitin-protein transferase activity
GO:0055088 ISS lipid homeostasis
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0097027 IDA ubiquitin-protein transferase activator activity
GO:1901800 IDA positive regulation of proteasomal protein catabolic process
GO:1902806 TAS regulation of cell cycle G1/S phase transition
GO:1903378 IDA positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990452 IPI Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 IDA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000346 ISS negative regulation of hepatocyte proliferation
GO:2000639 ISS negative regulation of SREBP signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060994 FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000028086 Fbxw7 F-box and WD-40 domain protein 7 protein_coding Mus_musculus

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