C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: F-box and WD-40 domain protein 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028086 Fbxw7 10090 + 3:84815268-84979198 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029727 Fbxw7-002 84952146-84977645 protein_coding
  ENSMUST00000107675 Fbxw7-005 84925480-84979197 protein_coding
  ENSMUST00000107678 Fbxw7-003 84864145-84979198 protein_coding
  ENSMUST00000107679 Fbxw7-001 84815268-84979198 protein_coding
  ENSMUST00000151410 Fbxw7-004 84815478-84977682 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029727ENSMUST00000107675ENSMUST00000107678ENSMUST00000107679
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029727 N/A N/A 18.411±16.00 1.485±0.00 N/A N/A N/A N/A N/A N/A 3.268±0.82 N/A N/A
ENSMUST00000107675 0.744±0.23 N/A N/A 1.216±0.57 1.961±0.50 11.165±1.62 0.956±0.33 0.793±0.35 2.141±0.29 4.691±0.68 3.096±0.61 N/A N/A
ENSMUST00000107678 0.402±0.00 1.381±0.09 2.788±0.60 1.076±0.00 0.933±0.00 N/A 0.587±0.26 0.602±0.21 N/A N/A 4.107±1.34 1.746±0.68 2.804±1.62
ENSMUST00000107679 1.531±0.25 2.624±0.04 3.700±2.08 1.459±0.00 N/A N/A 0.669±0.20 0.729±0.35 N/A 1.160±0.22 5.425±0.00 3.165±1.82 2.958±0.93

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00064N CIL_00064N_0002 CGP 3:84444035-85887516
CIL_0004PH CIL_0004PH_0002 CGP 3:84496093-85887516
CIL_0008CH CIL_0008CH_0002 VISTA 3:84637097-85239573

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001570 IMP vasculogenesis
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 IEA nucleoplasm
GO:0005730 IEA nucleolus
GO:0005737 TAS cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006974 ISS cellular response to DNA damage stimulus
GO:0007062 ISS sister chromatid cohesion
GO:0007219 IDA Notch signaling pathway
GO:0016021 NAS integral component of membrane
GO:0016567 ISS protein ubiquitination
GO:0019005 ISS SCF ubiquitin ligase complex
GO:0030324 IMP lung development
GO:0030332 ISS cyclin binding
GO:0030674 ISS protein binding, bridging
GO:0031146 ISS SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 ISS positive regulation of protein ubiquitination
GO:0031625 ISS ubiquitin protein ligase binding
GO:0032876 ISS negative regulation of DNA endoreduplication
GO:0034644 ISS cellular response to UV
GO:0042802 ISS identical protein binding
GO:0043234 IEA protein complex
GO:0045741 ISS positive regulation of epidermal growth factor-activated receptor activity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051443 ISS positive regulation of ubiquitin-protein transferase activity
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0097027 ISS ubiquitin-protein transferase activator activity
GO:1901800 IMP positive regulation of proteasomal protein catabolic process
GO:1903378 IMP positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990452 ISS Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 ISS positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060994 FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000109670 FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase protein_coding Homo_sapiens

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