C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000263981 FBXW7-005 ENSG00000109670 9606 - 4:152321263-152352971 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastKidneyENST00000263981
Transcript ID Brain Breast Kidney
ENST00000263981 31.272±3.27 3.347±0.00 1.356±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008CH CIL_0008CH_0001 VISTA 4:152066503-152669365

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001944 TAS vasculature development
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007062 IMP sister chromatid cohesion
GO:0007219 TAS Notch signaling pathway
GO:0010868 ISS negative regulation of triglyceride biosynthetic process
GO:0010883 ISS regulation of lipid storage
GO:0016032 IEA viral process
GO:0016567 IDA protein ubiquitination
GO:0019005 IDA SCF ubiquitin ligase complex
GO:0030332 IDA cyclin binding
GO:0030674 IDA protein binding, bridging
GO:0031146 IDA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032876 IMP negative regulation of DNA endoreduplication
GO:0032880 ISS regulation of protein localization
GO:0034644 IDA cellular response to UV
GO:0042802 IPI identical protein binding
GO:0043234 IDA protein complex
GO:0045741 IDA positive regulation of epidermal growth factor-activated receptor activity
GO:0045746 ISS negative regulation of Notch signaling pathway
GO:0050821 IDA protein stabilization
GO:0051443 IDA positive regulation of ubiquitin-protein transferase activity
GO:0055088 ISS lipid homeostasis
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0097027 IDA ubiquitin-protein transferase activator activity
GO:1901800 IDA positive regulation of proteasomal protein catabolic process
GO:1902806 TAS regulation of cell cycle G1/S phase transition
GO:1903378 IDA positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1990452 IPI Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 IDA positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000346 ISS negative regulation of hepatocyte proliferation
GO:2000639 ISS negative regulation of SREBP signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029727 Fbxw7-002 protein_coding Mus_musculus 0 3112
ENSMUST00000107678 Fbxw7-003 protein_coding Mus_musculus 0 2409
ENSMUST00000107679 Fbxw7-001 protein_coding Mus_musculus 0 2409
ENSMUST00000107675 Fbxw7-005 protein_coding Mus_musculus 0 2403
ENSMUST00000151410 Fbxw7-004 retained_intron Mus_musculus 0 1744
ENSDART00000086512 FBXW7-201 protein_coding Danio_rerio 2e-25 122

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