C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111361 EIF2B1 9606 - 12:123620406-123633766 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000424014 EIF2B1-001 123620406-123633766 protein_coding
  ENST00000452159 EIF2B1-005 123630047-123633688 retained_intron
  ENST00000534960 EIF2B1-007 123622636-123633604 protein_coding
  ENST00000537073 EIF2B1-002 123625967-123633766 protein_coding
  ENST00000539951 EIF2B1-004 123621738-123632447 protein_coding
  ENST00000543940 EIF2B1-006 123630234-123633657 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000424014ENST00000452159ENST00000534960ENST00000537073ENST00000539951
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000424014 2.979±0.00 14.394±0.00 1.114±0.00 6.478±2.55 8.363±1.55 6.540±0.55 1.858±0.00 6.579±3.30 5.655±2.22 4.713±0.67 N/A 11.350±6.09 7.459±1.73 9.839±1.20
ENST00000452159 N/A N/A 4.863±0.00 N/A N/A N/A N/A N/A 8.841±0.00 N/A 7.902±0.00 N/A N/A N/A
ENST00000534960 N/A N/A N/A N/A N/A N/A N/A 7.894±0.00 N/A N/A N/A 9.641±0.00 N/A N/A
ENST00000537073 N/A N/A 1.911±0.00 4.147±0.00 N/A N/A N/A N/A N/A 7.592±0.00 N/A N/A N/A N/A
ENST00000539951 11.236±0.00 N/A N/A N/A 22.006±0.00 12.130±0.00 N/A 18.649±0.00 N/A N/A 9.581±0.00 N/A N/A 24.701±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003J8 CIL_0003J8_0001 CGP 12:123584531-123620941
CIL_000395 CIL_000395_0001 CGP 12:123602077-123633766
CIL_00006O CIL_00006O_0002 CGP 12:123620406-123662606

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003743 IDA translation initiation factor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005525 IEA GTP binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005851 IDA eukaryotic translation initiation factor 2B complex
GO:0005886 IDA plasma membrane
GO:0006412 TAS translation
GO:0006413 IDA translational initiation
GO:0006417 IEA regulation of translation
GO:0006446 IBA regulation of translational initiation
GO:0009408 ISS response to heat
GO:0009749 ISS response to glucose
GO:0010467 TAS gene expression
GO:0014003 IMP oligodendrocyte development
GO:0016020 IDA membrane
GO:0019003 IEA GDP binding
GO:0030234 IEA enzyme regulator activity
GO:0032057 IEA negative regulation of translational initiation in response to stress
GO:0043434 ISS response to peptide hormone
GO:0043547 IDA positive regulation of GTPase activity
GO:0044237 IEA cellular metabolic process
GO:0044267 TAS cellular protein metabolic process
GO:0050790 IEA regulation of catalytic activity
GO:0051716 IDA cellular response to stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000088185 eif2b1 eukaryotic translation initiation factor 2B, subunit 1 alpha protein_coding Danio_rerio
ENSDARG00000091402 eif2b1 eukaryotic translation initiation factor 2B, subunit 1 alpha protein_coding Danio_rerio
ENSMUSG00000029388 Eif2b1 eukaryotic translation initiation factor 2B, subunit 1 (alpha) protein_coding Mus_musculus

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