C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: IL2-inducible T-cell kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113263 ITK 9606 + 5:157142933-157255191 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000422843 ITK-001 157180826-157255191 protein_coding
  ENST00000517779 ITK-007 157180867-157214210 nonsense_mediated_decay
  ENST00000519402 ITK-002 157180843-157255099 retained_intron
  ENST00000519749 ITK-005 157241591-157255185 processed_transcript
  ENST00000519759 ITK-009 157222749-157240131 retained_intron
  ENST00000520173 ITK-010 157240093-157244275 retained_intron
  ENST00000520555 ITK-006 157180840-157211511 retained_intron
  ENST00000521769 ITK-008 157142933-157222963 protein_coding
  ENST00000522616 ITK-003 157180837-157195907 processed_transcript
  ENST00000523926 ITK-011 157244891-157245976 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonKidneyLungOvaryENST00000422843ENST00000519402ENST00000519749
Transcript ID Adrenal Breast Colon Kidney Lung Ovary
ENST00000422843 2.046±0.00 1.066±0.00 0.450±0.00 N/A 1.491±0.16 N/A
ENST00000519402 2.482±0.00 0.722±0.00 0.297±0.00 N/A 1.280±0.00 N/A
ENST00000519749 6.112±0.00 N/A N/A 0.924±0.00 1.725±0.00 0.645±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094M CIL_00094M_0001 VISTA 5:157087063-157688799
CIL_00023X CIL_00023X_0001 CGP 5:157142933-157255191

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001816 ISS cytokine production
GO:0001865 IEA NK T cell differentiation
GO:0002250 ISS adaptive immune response
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005911 IEA cell-cell junction
GO:0006468 IEA protein phosphorylation
GO:0006968 TAS cellular defense response
GO:0007165 TAS signal transduction
GO:0007202 ISS activation of phospholipase C activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0032609 IEA interferon-gamma production
GO:0032633 IEA interleukin-4 production
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042110 TAS T cell activation
GO:0045087 TAS innate immune response
GO:0046872 IEA metal ion binding
GO:0050852 ISS T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017565 itk IL2-inducible T-cell kinase protein_coding Danio_rerio
ENSMUSG00000020395 Itk IL2 inducible T cell kinase protein_coding Mus_musculus

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