C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: IL2 inducible T cell kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020395 Itk 10090 - 11:46325150-46389515 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020664 Itk-001 46325150-46389515 protein_coding
  ENSMUST00000101306 Itk-002 46344478-46389457 protein_coding
  ENSMUST00000109237 Itk-004 46325150-46389493 protein_coding
  ENSMUST00000155991 Itk-003 46363103-46389461 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020664ENSMUST00000101306ENSMUST00000109237
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020664 0.175±0.13 0.058±0.04 0.199±0.02 0.011±0.00 4.475±2.03 0.338±0.14 0.208±0.06 0.382±0.36 0.070±0.05 1.023±0.03 0.196±0.27 0.106±0.08 1.015±0.81 0.007±0.00
ENSMUST00000101306 0.098±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.112±0.00 0.835±0.00 0.089±0.00
ENSMUST00000109237 0.049±0.02 0.020±0.01 N/A 0.011±0.00 N/A 0.223±0.07 N/A 0.026±0.01 0.047±0.03 N/A 0.007±0.00 0.085±0.07 0.085±0.00 0.007±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094M CIL_00094M_0002 VISTA 11:45901358-46503267
CIL_00023X CIL_00023X_0002 CGP 11:46325150-46407982

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001816 IMP cytokine production
GO:0001865 IGI NK T cell differentiation
GO:0002250 IMP adaptive immune response
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 ISS non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005911 IDA cell-cell junction
GO:0007202 IMP activation of phospholipase C activity
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0032609 IGI interferon-gamma production
GO:0032633 IGI interleukin-4 production
GO:0035556 IEA intracellular signal transduction
GO:0046872 IEA metal ion binding
GO:0050852 IMP T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017565 itk IL2-inducible T-cell kinase protein_coding Danio_rerio
ENSG00000113263 ITK IL2-inducible T-cell kinase protein_coding Homo_sapiens

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