C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: IL2-inducible T-cell kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000422843 ITK-001 ENSG00000113263 9606 + 5:157180826-157255191 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonLungENST00000422843
Transcript ID Adrenal Breast Colon Lung
ENST00000422843 2.046±0.00 1.066±0.00 0.450±0.00 1.491±0.16

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00094M CIL_00094M_0001 VISTA 5:157087063-157688799
CIL_00023X CIL_00023X_0001 CGP 5:157142933-157255191

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001816 ISS cytokine production
GO:0001865 IEA NK T cell differentiation
GO:0002250 ISS adaptive immune response
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IDA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005911 IEA cell-cell junction
GO:0006468 IEA protein phosphorylation
GO:0006968 TAS cellular defense response
GO:0007165 TAS signal transduction
GO:0007202 ISS activation of phospholipase C activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0032609 IEA interferon-gamma production
GO:0032633 IEA interleukin-4 production
GO:0035556 IEA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042110 TAS T cell activation
GO:0045087 TAS innate immune response
GO:0046872 IEA metal ion binding
GO:0050852 ISS T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020664 Itk-001 protein_coding Mus_musculus 0 2281
ENSMUST00000109237 Itk-004 protein_coding Mus_musculus 0 2204
ENSMUST00000101306 Itk-002 protein_coding Mus_musculus 0 976

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