C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113580 NR3C1 9606 - 5:143277931-143435512 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000231509 NR3C1-001 143281162-143403689 protein_coding
  ENST00000343796 NR3C1-201 143277931-143435512 protein_coding
  ENST00000394464 NR3C1-002 143277931-143403700 protein_coding
  ENST00000394466 NR3C1-006 143281138-143404129 protein_coding
  ENST00000415690 NR3C1-003 143277936-143403329 protein_coding
  ENST00000424646 NR3C1-202 143279567-143400852 protein_coding
  ENST00000502500 NR3C1-013 143400408-143401397 protein_coding
  ENST00000502892 NR3C1-008 143400404-143404667 protein_coding
  ENST00000503201 NR3C1-007 143281811-143404544 protein_coding
  ENST00000503701 NR3C1-011 143408990-143434774 processed_transcript
  ENST00000504336 NR3C1-014 143300561-143390001 processed_transcript
  ENST00000504572 NR3C1-010 143281120-143434702 protein_coding
  ENST00000505058 NR3C1-012 143408990-143434772 processed_transcript
  ENST00000508760 NR3C1-005 143400404-143403882 protein_coding
  ENST00000510170 NR3C1-004 143400404-143402737 protein_coding
  ENST00000514699 NR3C1-009 143400404-143405323 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000231509ENST00000394464ENST00000415690ENST00000424646ENST00000503201ENST00000504336
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000231509 N/A N/A N/A 2.928±0.00 N/A 2.660±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000394464 2.911±0.00 1.692±0.00 2.373±0.00 2.098±0.00 5.129±1.11 2.757±0.29 1.844±0.34 4.335±0.00 5.401±4.16 5.423±2.14 6.182±1.69 1.120±0.37 2.716±0.34 N/A
ENST00000415690 3.290±0.00 3.039±0.00 N/A 5.344±0.00 3.660±0.00 3.325±0.00 N/A 2.376±0.00 N/A N/A N/A 1.865±1.25 1.910±0.00 2.876±1.82
ENST00000424646 N/A N/A N/A N/A N/A 1.982±0.00 1.072±0.00 3.432±0.00 6.813±0.00 N/A N/A 1.208±0.00 N/A N/A
ENST00000503201 N/A N/A 1.776±0.00 N/A N/A N/A 3.320±0.00 4.835±0.00 N/A 7.358±0.00 3.655±0.00 3.908±0.00 N/A N/A
ENST00000504336 N/A N/A 10.122±0.00 20.868±0.00 N/A N/A N/A 18.378±0.00 N/A 34.040±0.00 12.316±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004883 IEA glucocorticoid receptor activity
GO:0005496 IEA steroid binding
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005759 TAS mitochondrial matrix
GO:0005829 IEA cytosol
GO:0006111 IEA regulation of gluconeogenesis
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IDA:IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007165 TAS signal transduction
GO:0008211 IEA glucocorticoid metabolic process
GO:0008270 IEA zinc ion binding
GO:0010467 TAS gene expression
GO:0016020 IEA membrane
GO:0016568 IEA chromatin modification
GO:0030325 IEA adrenal gland development
GO:0031946 IEA regulation of glucocorticoid biosynthetic process
GO:0042711 IEA maternal behavior
GO:0042921 IEA glucocorticoid receptor signaling pathway
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043402 IEA glucocorticoid mediated signaling pathway
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0060603 IEA mammary gland duct morphogenesis
GO:1900170 IEA negative regulation of glucocorticoid mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025032 nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) protein_coding Danio_rerio
ENSMUSG00000024431 Nr3c1 nuclear receptor subfamily 3, group C, member 1 protein_coding Mus_musculus

Loading