C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hes family bHLH transcription factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114315 HES1 9606 + 3:194136145-194138732 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000232424 HES1-001 194136145-194138732 protein_coding
  ENST00000476918 HES1-002 194136148-194137284 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000232424ENST00000476918
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000232424 18.832±0.00 14.011±0.00 5.316±0.00 2.463±0.37 10.160±2.89 7.947±1.63 2.322±0.93 12.817±9.85 7.715±1.55 21.694±13.98 8.515±1.76 34.589±16.81 16.048±1.08 11.201±0.16
ENST00000476918 N/A N/A N/A N/A N/A N/A N/A N/A 3.508±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UX CIL_0007UX_0001 VISTA 3:193643028-194244689
CIL_0009B1 CIL_0009B1_0001 VISTA 3:193659729-194262381
CIL_0009A1 CIL_0009A1_0001 VISTA 3:193911571-194513668
CIL_0000N7 CIL_0000N7_0001 CGP 3:194136145-194351328

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001078 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0003143 ISS embryonic heart tube morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003266 ISS regulation of secondary heart field cardioblast proliferation
GO:0003281 ISS ventricular septum development
GO:0003677 TAS:IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006461 ISS protein complex assembly
GO:0007155 IEA cell adhesion
GO:0007219 IDA Notch signaling pathway
GO:0007224 IEA smoothened signaling pathway
GO:0007262 ISS STAT protein import into nucleus
GO:0007389 IEA pattern specification process
GO:0007399 TAS nervous system development
GO:0008134 NAS transcription factor binding
GO:0008284 ISS positive regulation of cell proliferation
GO:0016477 IEA cell migration
GO:0021537 IEA telencephalon development
GO:0021555 IEA midbrain-hindbrain boundary morphogenesis
GO:0021557 IEA oculomotor nerve development
GO:0021558 IEA trochlear nerve development
GO:0021575 IEA hindbrain morphogenesis
GO:0021861 ISS forebrain radial glial cell differentiation
GO:0021915 IEA neural tube development
GO:0021983 IEA pituitary gland development
GO:0021984 IEA adenohypophysis development
GO:0030324 IEA lung development
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0030901 IEA midbrain development
GO:0031016 IEA pancreas development
GO:0031018 TAS endocrine pancreas development
GO:0035019 IEA somatic stem cell maintenance
GO:0035909 IEA aorta morphogenesis
GO:0035910 ISS ascending aorta morphogenesis
GO:0042102 IEA positive regulation of T cell proliferation
GO:0042491 IEA auditory receptor cell differentiation
GO:0042517 ISS positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042668 IEA auditory receptor cell fate determination
GO:0042803 ISS protein homodimerization activity
GO:0042826 IPI histone deacetylase binding
GO:0043388 ISS positive regulation of DNA binding
GO:0043565 ISS sequence-specific DNA binding
GO:0045165 IEA cell fate commitment
GO:0045596 IEA negative regulation of cell differentiation
GO:0045598 IEA regulation of fat cell differentiation
GO:0045608 IEA negative regulation of auditory receptor cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045747 IEA positive regulation of Notch signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0045977 ISS positive regulation of mitotic cell cycle, embryonic
GO:0046331 IEA lateral inhibition
GO:0046427 ISS positive regulation of JAK-STAT cascade
GO:0046983 IEA protein dimerization activity
GO:0048469 IEA cell maturation
GO:0048505 IEA regulation of timing of cell differentiation
GO:0048538 ISS thymus development
GO:0048667 IEA cell morphogenesis involved in neuron differentiation
GO:0048711 ISS positive regulation of astrocyte differentiation
GO:0048715 ISS negative regulation of oligodendrocyte differentiation
GO:0048844 ISS artery morphogenesis
GO:0050767 IEA regulation of neurogenesis
GO:0051087 IEA chaperone binding
GO:0060164 IEA regulation of timing of neuron differentiation
GO:0060253 ISS negative regulation of glial cell proliferation
GO:0060412 ISS ventricular septum morphogenesis
GO:0060675 IEA ureteric bud morphogenesis
GO:0060716 IEA labyrinthine layer blood vessel development
GO:0061009 IEA common bile duct development
GO:0061106 IEA negative regulation of stomach neuroendocrine cell differentiation
GO:0061309 ISS cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061626 ISS pharyngeal arch artery morphogenesis
GO:0071820 ISS N-box binding
GO:0072012 IEA glomerulus vasculature development
GO:0072049 IEA comma-shaped body morphogenesis
GO:0072050 IEA S-shaped body morphogenesis
GO:0072141 IEA renal interstitial fibroblast development
GO:0072282 IEA metanephric nephron tubule morphogenesis
GO:0090102 IEA cochlea development
GO:0097084 ISS vascular smooth muscle cell development
GO:0097150 IEP neuronal stem cell maintenance
GO:2000227 IEA negative regulation of pancreatic A cell differentiation
GO:2000737 IMP negative regulation of stem cell differentiation
GO:2000974 IMP negative regulation of pro-B cell differentiation
GO:2000978 ISS negative regulation of forebrain neuron differentiation
GO:2000981 IEA negative regulation of inner ear receptor cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006514 her6 hairy-related 6 protein_coding Danio_rerio
ENSMUSG00000022528 Hes1 hairy and enhancer of split 1 (Drosophila) protein_coding Mus_musculus

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