C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HtrA serine peptidase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115317 HTRA2 9606 + 2:74529377-74533348 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000258080 HTRA2-001 74529377-74533348 protein_coding
  ENST00000352222 HTRA2-002 74529990-74533332 protein_coding
  ENST00000437202 HTRA2-005 74530046-74533192 protein_coding
  ENST00000462909 HTRA2-003 74529725-74533152 processed_transcript
  ENST00000465521 HTRA2-010 74530426-74531363 retained_intron
  ENST00000467961 HTRA2-004 74529775-74533247 processed_transcript
  ENST00000482205 HTRA2-009 74530597-74531249 retained_intron
  ENST00000482331 HTRA2-007 74530611-74531912 retained_intron
  ENST00000484352 HTRA2-006 74530169-74533316 retained_intron
  ENST00000484881 HTRA2-008 74529822-74531925 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartOvaryTestisENST00000258080
Transcript ID Adipose Brain Breast Colon Heart Ovary Testis
ENST00000258080 20.087±0.00 6.149±0.00 13.239±0.00 14.790±0.00 4.890±0.00 24.034±0.00 13.042±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000785 IDA chromatin
GO:0003824 IEA catalytic activity
GO:0004252 TAS:IEA serine-type endopeptidase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005739 IDA mitochondrion
GO:0005758 IDA mitochondrial intermembrane space
GO:0005783 NAS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005829 IDA cytosol
GO:0005856 IDA cytoskeleton
GO:0006508 TAS:IEA proteolysis
GO:0006672 IEA ceramide metabolic process
GO:0007005 IEA mitochondrion organization
GO:0007628 IEA adult walking behavior
GO:0008233 IDA peptidase activity
GO:0008236 IDA serine-type peptidase activity
GO:0008344 IEA adult locomotory behavior
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 IEA response to herbicide
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0010942 IDA positive regulation of cell death
GO:0016020 IDA membrane
GO:0016540 TAS protein autoprocessing
GO:0019742 IEA pentacyclic triterpenoid metabolic process
GO:0030900 IEA forebrain development
GO:0034599 NAS cellular response to oxidative stress
GO:0034605 IDA cellular response to heat
GO:0035458 IDA cellular response to interferon-beta
GO:0035631 ISS CD40 receptor complex
GO:0040014 IEA regulation of multicellular organism growth
GO:0043065 TAS positive regulation of apoptotic process
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 IDA cellular protein catabolic process
GO:0045786 TAS negative regulation of cell cycle
GO:0048666 IEA neuron development
GO:0051082 NAS unfolded protein binding
GO:0060548 IEA negative regulation of cell death
GO:0071300 IDA cellular response to retinoic acid
GO:0071363 IMP cellular response to growth factor stimulus
GO:0097193 IEA intrinsic apoptotic signaling pathway
GO:0097194 TAS execution phase of apoptosis
GO:1901215 TAS negative regulation of neuron death
GO:1902176 NAS negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903146 TAS regulation of mitochondrion degradation
GO:2001241 IMP positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068667 HTRA2 (1 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000068800 HTRA2 (2 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000068819 HTRA2 (3 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000069909 HTRA2 (4 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000070138 HTRA2 (5 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000076713 HTRA2 (6 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000088743 HTRA2 (7 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000089070 HTRA2 (8 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000090177 HTRA2 (9 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092061 HTRA2 (10 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092094 HTRA2 (11 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092133 HTRA2 (12 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092202 HTRA2 (13 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092380 HTRA2 (14 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092625 HTRA2 (15 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000092951 HTRA2 (16 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000093005 HTRA2 (17 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000093522 HTRA2 (18 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000093729 HTRA2 (19 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000093963 HTRA2 (20 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094236 HTRA2 (21 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094403 HTRA2 (22 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094713 HTRA2 (23 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094741 HTRA2 (24 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094749 HTRA2 (25 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094878 HTRA2 (26 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000094995 HTRA2 (27 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000095314 HTRA2 (28 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000095444 HTRA2 (29 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000095545 HTRA2 (30 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSDARG00000095687 HTRA2 (31 of 31) HtrA serine peptidase 2 protein_coding Danio_rerio
ENSMUSG00000068329 Htra2 HtrA serine peptidase 2 protein_coding Mus_musculus

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