C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: HtrA serine peptidase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000258080 HTRA2-001 ENSG00000115317 9606 + 2:74529377-74533348 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastColonHeartOvaryTestisENST00000258080
Transcript ID Adipose Brain Breast Colon Heart Ovary Testis
ENST00000258080 20.087±0.00 6.149±0.00 13.239±0.00 14.790±0.00 4.890±0.00 24.034±0.00 13.042±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000785 IDA chromatin
GO:0003824 IEA catalytic activity
GO:0004252 TAS:IEA serine-type endopeptidase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005739 IDA mitochondrion
GO:0005758 IDA mitochondrial intermembrane space
GO:0005783 NAS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005829 IDA cytosol
GO:0005856 IDA cytoskeleton
GO:0006508 TAS:IEA proteolysis
GO:0006672 IEA ceramide metabolic process
GO:0007005 IEA mitochondrion organization
GO:0007628 IEA adult walking behavior
GO:0008233 IDA peptidase activity
GO:0008236 IDA serine-type peptidase activity
GO:0008344 IEA adult locomotory behavior
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635 IEA response to herbicide
GO:0009898 ISS cytoplasmic side of plasma membrane
GO:0010942 IDA positive regulation of cell death
GO:0016020 IDA membrane
GO:0016540 TAS protein autoprocessing
GO:0019742 IEA pentacyclic triterpenoid metabolic process
GO:0030900 IEA forebrain development
GO:0034599 NAS cellular response to oxidative stress
GO:0034605 IDA cellular response to heat
GO:0035458 IDA cellular response to interferon-beta
GO:0035631 ISS CD40 receptor complex
GO:0040014 IEA regulation of multicellular organism growth
GO:0043065 TAS positive regulation of apoptotic process
GO:0043280 IDA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 IDA cellular protein catabolic process
GO:0045786 TAS negative regulation of cell cycle
GO:0048666 IEA neuron development
GO:0051082 NAS unfolded protein binding
GO:0060548 IEA negative regulation of cell death
GO:0071300 IDA cellular response to retinoic acid
GO:0071363 IMP cellular response to growth factor stimulus
GO:0097193 IEA intrinsic apoptotic signaling pathway
GO:0097194 TAS execution phase of apoptosis
GO:1901215 TAS negative regulation of neuron death
GO:1902176 NAS negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903146 TAS regulation of mitochondrion degradation
GO:2001241 IMP positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001269 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000089645 Htra2-001 protein_coding Mus_musculus 0 1663
ENSMUST00000113963 Htra2-004 protein_coding Mus_musculus 0 1234
ENSMUST00000154829 Htra2-006 retained_intron Mus_musculus 0 1195
ENSMUST00000134606 Htra2-007 protein_coding Mus_musculus 0 1114
ENSMUST00000122955 Htra2-003 nonsense_mediated_decay Mus_musculus 0 987
ENSMUST00000150217 Htra2-005 protein_coding Mus_musculus 0 673
ENSMUST00000113962 Htra2-002 protein_coding Mus_musculus 0 625
ENSMUST00000144058 Htra2-009 retained_intron Mus_musculus 0 569
ENSMUST00000132099 Htra2-008 nonsense_mediated_decay Mus_musculus 0 507
ENSMUST00000101257 Loxl3-002 protein_coding Mus_musculus 0 377
ENSMUST00000000707 Loxl3-001 protein_coding Mus_musculus 0 377
ENSMUST00000092618 Aup1-201 protein_coding Mus_musculus 7e-28 130

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