C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: isoprenylcysteine carboxyl methyltransferase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116237 ICMT 9606 - 1:6221193-6235972 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000343813 ICMT-001 6221193-6235940 protein_coding
  ENST00000474756 ICMT-006 6224599-6235972 nonsense_mediated_decay
  ENST00000489498 ICMT-002 6223491-6235972 nonsense_mediated_decay
  ENST00000495791 ICMT-005 6221898-6223502 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343813ENST00000489498
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343813 18.055±0.00 19.852±0.00 3.662±0.00 5.722±2.48 19.937±0.00 10.838±6.26 13.408±0.00 24.462±0.00 7.306±0.00 5.971±2.27 14.503±9.35 13.954±0.00 21.334±0.57 16.834±0.00
ENST00000489498 N/A N/A N/A N/A N/A N/A 13.331±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00019L CIL_00019L_0002 CGP 1:6181269-6221299

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0001889 IEA liver development
GO:0003880 TAS protein C-terminal carboxyl O-methyltransferase activity
GO:0004671 IEA protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0005783 IDA endoplasmic reticulum
GO:0006464 TAS cellular protein modification process
GO:0006479 IEA protein methylation
GO:0006481 IEA C-terminal protein methylation
GO:0006612 TAS protein targeting to membrane
GO:0008104 IEA protein localization
GO:0008140 IEA cAMP response element binding protein binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0016020 TAS membrane
GO:0016021 IEA integral component of membrane
GO:0035264 IEA multicellular organism growth
GO:0046578 IEA regulation of Ras protein signal transduction
GO:2001141 IEA regulation of RNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020241 icmt isoprenylcysteine carboxyl methyltransferase protein_coding Danio_rerio
ENSMUSG00000039662 Icmt isoprenylcysteine carboxyl methyltransferase protein_coding Mus_musculus

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