C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ribosomal protein S6 kinase, 90kDa, polypeptide 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000117676 RPS6KA1 9606 + 1:26529761-26575030 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000366866 RPS6KA1-016 26543130-26553426 nonsense_mediated_decay
  ENST00000374163 RPS6KA1-002 26545842-26575030 nonsense_mediated_decay
  ENST00000374166 RPS6KA1-010 26529778-26575014 protein_coding
  ENST00000374168 RPS6KA1-001 26529767-26575025 protein_coding
  ENST00000403732 RPS6KA1-007 26557043-26571508 protein_coding
  ENST00000438977 RPS6KA1-006 26572270-26574734 protein_coding
  ENST00000474934 RPS6KA1-004 26551446-26554135 retained_intron
  ENST00000488985 RPS6KA1-005 26555199-26557036 processed_transcript
  ENST00000524436 RPS6KA1-014 26529775-26551503 retained_intron
  ENST00000525525 RPS6KA1-012 26529761-26546983 nonsense_mediated_decay
  ENST00000525582 RPS6KA1-018 26546900-26547590 retained_intron
  ENST00000526040 RPS6KA1-013 26529761-26553461 nonsense_mediated_decay
  ENST00000526792 RPS6KA1-009 26531218-26574431 protein_coding
  ENST00000527264 RPS6KA1-019 26547243-26554447 retained_intron
  ENST00000529454 RPS6KA1-015 26531328-26554251 protein_coding
  ENST00000530003 RPS6KA1-003 26543112-26575014 protein_coding
  ENST00000530305 RPS6KA1-020 26571229-26572021 retained_intron
  ENST00000530607 RPS6KA1-017 26545845-26551586 retained_intron
  ENST00000531113 RPS6KA1-011 26543162-26572233 retained_intron
  ENST00000531382 RPS6KA1-008 26545852-26574276 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374163ENST00000374166ENST00000374168ENST00000438977ENST00000524436ENST00000525582ENST00000526792ENST00000530003ENST00000531382
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374163 N/A N/A N/A N/A N/A N/A 0.297±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000374166 N/A N/A N/A N/A N/A N/A N/A 5.215±0.00 N/A 10.716±0.00 N/A N/A N/A 2.148±0.00
ENST00000374168 2.927±0.00 4.917±0.00 N/A 3.013±0.00 2.546±0.15 3.719±1.74 1.467±0.00 6.181±5.79 N/A 14.696±0.00 N/A 6.804±8.19 4.114±1.18 2.858±0.74
ENST00000438977 N/A 10.243±0.00 N/A 3.923±0.00 N/A N/A N/A N/A 0.603±0.00 N/A N/A N/A N/A N/A
ENST00000524436 N/A N/A N/A N/A N/A N/A N/A N/A 0.945±0.00 N/A 0.889±0.00 N/A N/A N/A
ENST00000525582 N/A N/A N/A N/A N/A N/A N/A N/A 1.066±0.00 N/A N/A N/A N/A N/A
ENST00000526792 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.072±0.00
ENST00000530003 N/A N/A 1.065±0.00 0.658±0.00 2.120±0.00 N/A 0.123±0.00 0.751±0.00 1.634±0.00 N/A 0.543±0.00 3.586±2.58 3.346±0.02 0.835±0.00
ENST00000531382 1.499±0.00 N/A N/A 2.172±0.00 0.776±0.00 N/A N/A 0.443±0.00 0.797±0.00 N/A N/A 2.282±0.00 1.487±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007T4 CIL_0007T4_0001 VISTA 1:26423129-27024414

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IEA magnesium ion binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004712 IDA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005819 IEA spindle
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030307 TAS positive regulation of cell growth
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 IEA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0043027 IDA cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043555 TAS regulation of translation in response to stress
GO:0043620 TAS regulation of DNA-templated transcription in response to stress
GO:0045087 TAS innate immune response
GO:0045597 TAS positive regulation of cell differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051403 TAS stress-activated MAPK cascade
GO:2000491 IMP positive regulation of hepatic stellate cell activation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033437 rps6ka1 ribosomal protein S6 kinase a, polypeptide 1 protein_coding Danio_rerio
ENSMUSG00000003644 Rps6ka1 ribosomal protein S6 kinase polypeptide 1 protein_coding Mus_musculus

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