C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine/threonine kinase 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118046 STK11 9606 + 19:1177558-1228435 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326873 STK11-001 1206464-1228435 protein_coding
  ENST00000585465 STK11-003 1223148-1228095 retained_intron
  ENST00000585748 STK11-007 1177558-1219386 protein_coding
  ENST00000585851 STK11-004 1206869-1220617 protein_coding
  ENST00000586243 STK11-201 1205805-1228094 protein_coding
  ENST00000586358 STK11-005 1207091-1221958 retained_intron
  ENST00000589152 STK11-002 1206824-1228012 retained_intron
  ENST00000591133 STK11-006 1220013-1223104 retained_intron
  ENST00000593219 STK11-009 1206816-1219357 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000326873ENST00000585465ENST00000585851ENST00000586243ENST00000586358
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000326873 8.948±0.00 8.208±0.00 N/A 4.013±0.86 8.148±0.00 5.934±3.66 3.944±1.22 4.277±2.48 3.160±1.39 2.775±2.18 7.886±5.52 6.880±1.97 11.551±4.75 18.251±0.00
ENST00000585465 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.143±0.00 N/A N/A
ENST00000585851 N/A N/A N/A 16.786±0.00 22.323±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000586243 22.587±0.00 17.432±0.00 1.838±0.00 6.094±4.16 9.272±7.92 8.233±6.15 19.435±0.00 9.532±7.08 5.114±3.59 12.164±10.61 33.056±26.63 23.442±17.52 18.956±3.48 159.003±98.24
ENST00000586358 N/A N/A N/A N/A N/A N/A N/A N/A 2.027±0.00 2.057±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000QW CIL_0000QW_0001 CGP 19:1107636-1228435
CIL_0005ZG CIL_0005ZG_0002 CGP 19:1177558-1238027

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001558 ISS regulation of cell growth
GO:0001894 IEA tissue homeostasis
GO:0001944 ISS vasculature development
GO:0002039 IDA p53 binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 ISS cytosol
GO:0006112 TAS energy reserve metabolic process
GO:0006468 IDA:IEA protein phosphorylation
GO:0006914 IEA autophagy
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007050 IDA cell cycle arrest
GO:0007286 IEA spermatid development
GO:0007409 IEA axonogenesis
GO:0008285 IMP negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0010212 ISS response to ionizing radiation
GO:0016020 ISS membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030010 ISS establishment of cell polarity
GO:0030111 IEA regulation of Wnt signaling pathway
GO:0030275 IEA LRR domain binding
GO:0030295 IDA protein kinase activator activity
GO:0030308 ISS negative regulation of cell growth
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032147 IDA activation of protein kinase activity
GO:0032403 IEA protein complex binding
GO:0033762 IEA response to glucagon
GO:0033993 IEA response to lipid
GO:0036398 IEA TCR signalosome
GO:0036399 IEA TCR signalosome assembly
GO:0042304 TAS regulation of fatty acid biosynthetic process
GO:0042593 ISS glucose homeostasis
GO:0043234 IEA protein complex
GO:0043276 IMP anoikis
GO:0043434 IEA response to peptide hormone
GO:0044281 TAS small molecule metabolic process
GO:0045059 IEA positive thymic T cell selection
GO:0045722 IEA positive regulation of gluconeogenesis
GO:0046777 IDA protein autophosphorylation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050772 IEA positive regulation of axonogenesis
GO:0050852 IEA T cell receptor signaling pathway
GO:0051291 IEA protein heterooligomerization
GO:0051645 IEA Golgi localization
GO:0051896 IEA regulation of protein kinase B signaling
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060770 IEA negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0070062 IDA extracellular vesicular exosome
GO:0072332 IDA intrinsic apoptotic signaling pathway by p53 class mediator

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000046074 stk11 serine/threonine kinase 11 protein_coding Danio_rerio
ENSMUSG00000003068 Stk11 serine/threonine kinase 11 protein_coding Mus_musculus

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