C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120254 MTHFD1L 9606 + 6:150865549-151101887 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000367307 MTHFD1L-012 150865716-150899021 protein_coding
  ENST00000367308 MTHFD1L-008 150865944-150926153 protein_coding
  ENST00000367321 MTHFD1L-003 150865549-151101887 protein_coding
  ENST00000420192 MTHFD1L-007 151014880-151022355 protein_coding
  ENST00000421497 MTHFD1L-005 150905670-150912948 processed_transcript
  ENST00000423867 MTHFD1L-009 150866557-150887873 protein_coding
  ENST00000441122 MTHFD1L-004 150866506-150936915 nonsense_mediated_decay
  ENST00000450635 MTHFD1L-002 151036974-151042058 protein_coding
  ENST00000453602 MTHFD1L-001 151034532-151042064 protein_coding
  ENST00000478643 MTHFD1L-006 150971948-151009958 processed_transcript
  ENST00000611279 MTHFD1L-201 150865679-151101885 protein_coding
  ENST00000618312 MTHFD1L-202 150866333-151101885 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000367307ENST00000367308ENST00000367321ENST00000423867ENST00000441122ENST00000453602ENST00000611279ENST00000618312
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000367307 3.316±0.00 5.115±0.00 N/A 1.919±0.00 N/A 2.408±0.00 N/A 2.018±0.00 0.676±0.00 13.312±0.00 N/A N/A 4.184±0.45 2.936±0.00
ENST00000367308 N/A N/A N/A N/A N/A N/A 0.465±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000367321 0.876±0.00 N/A N/A 2.137±0.00 1.527±0.93 3.032±0.00 N/A 0.625±0.00 N/A N/A N/A 6.482±3.08 2.343±0.00 1.570±0.00
ENST00000423867 N/A N/A N/A N/A N/A N/A N/A N/A 1.099±0.00 N/A N/A N/A N/A N/A
ENST00000441122 N/A N/A 0.632±0.00 N/A 1.306±0.00 1.212±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000453602 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.334±0.00 N/A N/A N/A
ENST00000611279 N/A N/A N/A 0.359±0.00 N/A 0.465±0.00 0.227±0.15 2.546±0.00 0.198±0.00 13.538±0.00 0.242±0.00 16.950±0.00 5.324±0.00 3.240±0.00
ENST00000618312 2.794±0.00 5.954±0.00 0.301±0.00 0.989±0.05 1.243±0.00 N/A 0.122±0.09 0.431±0.00 0.821±0.00 0.490±0.00 N/A 9.269±5.00 5.333±0.56 2.563±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005ED CIL_0005ED_0001 CGP 6:150599863-151101887
CIL_0005EE CIL_0005EE_0001 CGP 6:150865549-151358557

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0004329 IDA formate-tetrahydrofolate ligase activity
GO:0004488 IEA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 IDA ATP binding
GO:0005739 IDA mitochondrion
GO:0006730 IBA one-carbon metabolic process
GO:0006760 IDA folic acid-containing compound metabolic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0015942 IDA formate metabolic process
GO:0016020 IDA membrane
GO:0035999 IEA tetrahydrofolate interconversion
GO:0042803 IDA protein homodimerization activity
GO:0046653 IDA tetrahydrofolate metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042221 mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like protein_coding Danio_rerio
ENSMUSG00000040675 Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like protein_coding Mus_musculus

Loading