C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: islet amyloid polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000121351 IAPP 9606 + 12:21354959-21379978 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000240652 IAPP-001 21372884-21379978 protein_coding
  ENST00000535428 IAPP-004 21373407-21378629 protein_coding
  ENST00000537593 IAPP-003 21372928-21378395 protein_coding
  ENST00000539393 IAPP-005 21354959-21378495 protein_coding
  ENST00000542023 IAPP-002 21372919-21379978 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungOvaryTestisENST00000240652ENST00000535428ENST00000537593ENST00000539393
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Ovary Testis
ENST00000240652 0.005±0.00 0.119±0.00 0.033±0.00 0.026±0.00 0.041±0.00 0.037±0.00 0.004±0.00 0.019±0.00 0.013±0.00 0.027±0.00
ENST00000535428 N/A N/A N/A N/A N/A 2.437±0.00 N/A N/A N/A 0.430±0.00
ENST00000537593 N/A N/A N/A N/A 0.157±0.00 N/A N/A N/A N/A N/A
ENST00000539393 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.234±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005PW CIL_0005PW_0001 CGP 12:21131202-21419594
CIL_0005PZ CIL_0005PZ_0001 CGP 12:21264600-21419594
CIL_0006XQ CIL_0006XQ_0002 CGP 12:21354959-21471252

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005102 TAS receptor binding
GO:0005179 IEA hormone activity
GO:0005576 TAS:IEA extracellular region
GO:0005615 IEA extracellular space
GO:0006915 TAS apoptotic process
GO:0007165 TAS signal transduction
GO:0007267 TAS cell-cell signaling
GO:0019233 IEA sensory perception of pain
GO:0031018 TAS endocrine pancreas development
GO:0042755 IEA eating behavior
GO:0042802 IPI identical protein binding
GO:0043025 IEA neuronal cell body
GO:0045596 IEA negative regulation of cell differentiation
GO:0045779 IEA negative regulation of bone resorption

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074122 IAPP islet amyloid polypeptide protein_coding Danio_rerio
ENSMUSG00000041681 Iapp islet amyloid polypeptide protein_coding Mus_musculus

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