C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol 1,4,5-trisphosphate receptor, type 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000123104 ITPR2 9606 - 12:26336515-26833198 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000242737 ITPR2-002 26721287-26832781 protein_coding
  ENST00000381340 ITPR2-001 26336515-26833198 protein_coding
  ENST00000451599 ITPR2-004 26387542-26494233 nonsense_mediated_decay
  ENST00000536627 ITPR2-009 26722438-26726013 processed_transcript
  ENST00000538984 ITPR2-008 26411213-26427937 retained_intron
  ENST00000540429 ITPR2-006 26494035-26495245 retained_intron
  ENST00000540791 ITPR2-010 26695602-26715728 processed_transcript
  ENST00000543958 ITPR2-007 26494206-26495560 retained_intron
  ENST00000545235 ITPR2-003 26716162-26832786 nonsense_mediated_decay
  ENST00000545902 ITPR2-011 26621182-26630714 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000381340
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000381340 2.034±0.00 1.385±0.00 5.576±0.00 1.715±0.71 2.956±1.15 1.735±1.28 1.264±0.50 7.912±5.86 0.907±0.09 3.134±2.10 0.100±0.00 1.462±0.78 2.013±1.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004XE CIL_0004XE_0001 CGP 12:26121991-26833198
CIL_0004XF CIL_0004XF_0001 CGP 12:26336515-26938326

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0005216 IEA ion channel activity
GO:0005220 IEA inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 IEA calcium channel activity
GO:0005488 IEA binding
GO:0005737 IEA cytoplasm
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005886 IDA plasma membrane
GO:0005938 IEA cell cortex
GO:0006112 TAS energy reserve metabolic process
GO:0006810 TAS transport
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0015085 TAS calcium ion transmembrane transporter activity
GO:0015278 IEA calcium-release channel activity
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0030168 TAS platelet activation
GO:0031095 TAS platelet dense tubular network membrane
GO:0033017 IMP sarcoplasmic reticulum membrane
GO:0035091 IEA phosphatidylinositol binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043235 IDA receptor complex
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048016 IEA inositol phosphate-mediated signaling
GO:0050796 TAS regulation of insulin secretion
GO:0055085 IEA transmembrane transport
GO:0070588 IEA calcium ion transmembrane transport
GO:0071320 IEA cellular response to cAMP
GO:0071361 IEA cellular response to ethanol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011909 itpr2 inositol 1,4,5-triphosphate receptor, type 2 protein_coding Danio_rerio
ENSMUSG00000030287 Itpr2 inositol 1,4,5-triphosphate receptor 2 protein_coding Mus_musculus

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