C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: potassium inwardly-rectifying channel, subfamily J, member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000123700 KCNJ2 9606 + 17:70168673-70180048 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000243457 KCNJ2-002 70169535-70180048 protein_coding
  ENST00000535240 KCNJ2-001 70168673-70176323 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000243457ENST00000535240
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000243457 0.741±0.00 0.282±0.00 1.562±0.80 1.094±0.02 1.614±0.00 5.177±1.70 0.293±0.00 0.456±0.00 1.126±0.44 1.663±0.88 0.409±0.04 1.621±0.92 0.138±0.00
ENST00000535240 N/A N/A N/A 0.795±0.00 0.985±0.00 N/A N/A N/A N/A 0.616±0.00 0.281±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001L0 CIL_0001L0_0002 CGP 17:70053429-70180048
CIL_00072G CIL_00072G_0001 CGP 17:70168673-72126420

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005242 IDA:IEA inward rectifier potassium channel activity
GO:0005515 IEA protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005790 IEA smooth endoplasmic reticulum
GO:0005791 IEA rough endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006813 IDA:IEA potassium ion transport
GO:0007268 TAS synaptic transmission
GO:0008076 IDA voltage-gated potassium channel complex
GO:0010107 IDA potassium ion import
GO:0014704 IEA intercalated disc
GO:0014861 IMP regulation of skeletal muscle contraction via regulation of action potential
GO:0015693 IEA magnesium ion transport
GO:0016021 IEA integral component of membrane
GO:0030007 TAS cellular potassium ion homeostasis
GO:0030315 IEA T-tubule
GO:0030425 IEA dendrite
GO:0031224 IDA intrinsic component of membrane
GO:0042802 IEA identical protein binding
GO:0043025 IEA neuronal cell body
GO:0043197 IEA dendritic spine
GO:0051289 IDA protein homotetramerization
GO:0055119 IMP relaxation of cardiac muscle
GO:0060075 TAS regulation of resting membrane potential
GO:0060306 IDA regulation of membrane repolarization
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071805 IDA potassium ion transmembrane transport
GO:0086001 IEA cardiac muscle cell action potential
GO:0086002 IMP cardiac muscle cell action potential involved in contraction
GO:0086004 IEA regulation of cardiac muscle cell contraction
GO:0086008 IMP voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086011 IMP membrane repolarization during action potential
GO:0086012 TAS membrane depolarization during cardiac muscle cell action potential
GO:0086013 IMP membrane repolarization during cardiac muscle cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:0090076 IMP relaxation of skeletal muscle
GO:1901381 IEA positive regulation of potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019418 kcnj2a potassium inwardly-rectifying channel, subfamily J, member 2a protein_coding Danio_rerio
ENSDARG00000038373 kcnj2b potassium inwardly-rectifying channel, subfamily J, member 2b protein_coding Danio_rerio
ENSMUSG00000041695 Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 protein_coding Mus_musculus

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