C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate receptor, metabotropic 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124493 GRM4 9606 - 6:34018645-34155622 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374177 GRM4-002 34021854-34155622 protein_coding
  ENST00000374181 GRM4-201 34018645-34146137 protein_coding
  ENST00000455714 GRM4-005 34022597-34102151 protein_coding
  ENST00000535756 GRM4-202 34018645-34103854 protein_coding
  ENST00000538487 GRM4-001 34021851-34146080 protein_coding
  ENST00000544773 GRM4-003 34022433-34111034 protein_coding
  ENST00000545715 GRM4-009 34022138-34063635 processed_transcript
  ENST00000607916 GRM4-006 34091584-34133756 retained_intron
  ENST00000609222 GRM4-004 34022178-34105967 protein_coding
  ENST00000609278 GRM4-010 34022821-34146092 nonsense_mediated_decay
  ENST00000609443 GRM4-011 34040705-34100088 protein_coding
  ENST00000609860 GRM4-008 34022185-34063239 retained_intron
  ENST00000609915 GRM4-012 34040711-34056323 processed_transcript
  ENST00000609973 GRM4-007 34054179-34133021 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000374177ENST00000374181ENST00000455714ENST00000538487ENST00000545715ENST00000607916ENST00000609222ENST00000609443ENST00000609860ENST00000609915ENST00000609973
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000374177 N/A 0.110±0.00 N/A 0.051±0.00 0.031±0.00 0.007±0.00 0.045±0.00 0.038±0.00 N/A N/A N/A 0.459±0.00
ENST00000374181 N/A N/A 0.154±0.00 N/A N/A N/A N/A N/A N/A N/A 0.082±0.00 N/A
ENST00000455714 N/A N/A 0.105±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000538487 N/A N/A 0.403±0.32 N/A N/A N/A N/A N/A N/A N/A 0.180±0.00 0.288±0.00
ENST00000545715 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.146±0.00 0.067±0.00 0.488±0.15
ENST00000607916 N/A N/A 0.136±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000609222 N/A N/A 0.312±0.17 N/A 0.098±0.00 N/A N/A N/A N/A 0.093±0.00 N/A 0.261±0.00
ENST00000609443 N/A N/A N/A N/A N/A N/A N/A N/A 0.042±0.00 0.113±0.00 N/A N/A
ENST00000609860 N/A N/A N/A N/A N/A N/A 0.016±0.00 N/A N/A 0.068±0.00 N/A N/A
ENST00000609915 N/A N/A N/A N/A N/A N/A N/A 0.246±0.00 N/A N/A N/A N/A
ENST00000609973 0.020±0.00 N/A N/A 0.033±0.00 0.014±0.00 0.007±0.00 N/A 0.004±0.00 N/A 0.016±0.00 N/A 0.079±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000251 CIL_000251_0001 CGP 6:34018645-34246231

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001642 IBA group III metabotropic glutamate receptor activity
GO:0004930 IMP:IEA G-protein coupled receptor activity
GO:0005516 IEA calmodulin binding
GO:0005622 IDA intracellular
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007196 IMP adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0007612 IEA learning
GO:0008066 IMP glutamate receptor activity
GO:0016021 IEA integral component of membrane
GO:0031410 IDA cytoplasmic vesicle
GO:0042734 IBA presynaptic membrane
GO:0043195 IEA terminal bouton
GO:0043198 IEA dendritic shaft
GO:0043410 IEP positive regulation of MAPK cascade
GO:0043523 TAS regulation of neuron apoptotic process
GO:0048306 IEA calcium-dependent protein binding
GO:0048787 IEA presynaptic active zone membrane
GO:0051966 IBA regulation of synaptic transmission, glutamatergic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040156 grm4 glutamate receptor, metabotropic 4 protein_coding Danio_rerio
ENSMUSG00000063239 Grm4 glutamate receptor, metabotropic 4 protein_coding Mus_musculus

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