C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124762 CDKN1A 9606 + 6:36676460-36687339 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000244741 CDKN1A-001 36678658-36687339 protein_coding
  ENST00000373711 CDKN1A-002 36678721-36685924 protein_coding
  ENST00000405375 CDKN1A-201 36678710-36687337 protein_coding
  ENST00000448526 CDKN1A-202 36676490-36687337 protein_coding
  ENST00000459970 CDKN1A-005 36676528-36684511 processed_transcript
  ENST00000462537 CDKN1A-003 36678771-36680857 processed_transcript
  ENST00000478800 CDKN1A-004 36678726-36684498 processed_transcript
  ENST00000615513 CDKN1A-203 36676460-36687337 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000244741ENST00000405375ENST00000448526ENST00000478800
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000244741 97.104±0.00 32.758±0.00 N/A 29.020±0.00 16.629±9.67 96.658±0.00 15.713±14.83 60.138±0.00 12.784±10.88 195.197±0.00 93.364±0.00 73.113±61.30 37.156±18.14 24.096±17.08
ENST00000405375 N/A N/A N/A N/A N/A N/A N/A N/A 3.916±0.00 57.572±0.00 6.199±0.00 N/A N/A N/A
ENST00000448526 N/A N/A N/A 1.007±0.00 N/A 8.053±0.00 N/A 0.972±0.00 N/A N/A 2.543±0.00 52.852±0.00 N/A 32.756±0.00
ENST00000478800 N/A N/A 1.437±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002YD CIL_0002YD_0001 CGP 6:36676460-36733183

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0004861 TAS:IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006977 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IDA:IEA cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 IEP Ras protein signal transduction
GO:0007346 IEA regulation of mitotic cell cycle
GO:0008285 IDA negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009411 IEA response to UV
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010165 IEA response to X-ray
GO:0010243 IEA response to organonitrogen compound
GO:0010629 IEA negative regulation of gene expression
GO:0014070 IEA response to organic cyclic compound
GO:0019912 IDA cyclin-dependent protein kinase activating kinase activity
GO:0030308 IDA negative regulation of cell growth
GO:0030332 IEA cyclin binding
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031100 IEA organ regeneration
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031668 IMP cellular response to extracellular stimulus
GO:0032403 IEA protein complex binding
GO:0033158 IEA regulation of protein import into nucleus, translocation
GO:0034605 IEA cellular response to heat
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042326 IDA negative regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042771 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 IEA negative regulation of apoptotic process
GO:0043068 IEA positive regulation of programmed cell death
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045087 TAS innate immune response
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046685 IEA response to arsenic-containing substance
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051384 IEA response to glucocorticoid
GO:0051412 IEA response to corticosterone
GO:0051726 IEA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0060574 IEA intestinal epithelial cell maturation
GO:0070557 IDA PCNA-p21 complex
GO:0071479 IMP cellular response to ionizing radiation
GO:0071850 IEA mitotic cell cycle arrest
GO:0090398 IMP cellular senescence
GO:0090400 TAS stress-induced premature senescence
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:2000278 IEA regulation of DNA biosynthetic process
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076554 cdkn1a cyclin-dependent kinase inhibitor 1A protein_coding Danio_rerio
ENSMUSG00000023067 Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) protein_coding Mus_musculus

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