C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000244741 CDKN1A-001 ENSG00000124762 9606 + 6:36678658-36687339 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000244741
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000244741 97.104±0.00 32.758±0.00 29.020±0.00 16.629±9.67 96.658±0.00 15.713±14.83 60.138±0.00 12.784±10.88 195.197±0.00 93.364±0.00 73.113±61.30 37.156±18.14 24.096±17.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002YD CIL_0002YD_0001 CGP 6:36676460-36733183

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0004861 TAS:IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006977 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IDA:IEA cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 IEP Ras protein signal transduction
GO:0008285 IDA negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0019912 IDA cyclin-dependent protein kinase activating kinase activity
GO:0030308 IDA negative regulation of cell growth
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031668 IMP cellular response to extracellular stimulus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042326 IDA negative regulation of phosphorylation
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045087 TAS innate immune response
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0070557 IDA PCNA-p21 complex
GO:0071479 IMP cellular response to ionizing radiation
GO:0090398 IMP cellular senescence
GO:0090400 TAS stress-induced premature senescence
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000122348 Cdkn1a-002 protein_coding Mus_musculus 0 309
ENSMUST00000023829 Cdkn1a-001 protein_coding Mus_musculus 0 309
ENSMUST00000119901 Cdkn1a-003 protein_coding Mus_musculus 0 309

Loading