C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000405375 CDKN1A-201 ENSG00000124762 9606 + 6:36678710-36687337 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; LiverLungMuscleENST00000405375
Transcript ID Liver Lung Muscle
ENST00000405375 3.916±0.00 57.572±0.00 6.199±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002YD CIL_0002YD_0001 CGP 6:36676460-36733183

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0004861 TAS:IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA protein phosphorylation
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006977 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IDA:IEA cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 IEP Ras protein signal transduction
GO:0007346 IEA regulation of mitotic cell cycle
GO:0008285 IDA negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009411 IEA response to UV
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010165 IEA response to X-ray
GO:0010243 IEA response to organonitrogen compound
GO:0010629 IEA negative regulation of gene expression
GO:0014070 IEA response to organic cyclic compound
GO:0019912 IDA cyclin-dependent protein kinase activating kinase activity
GO:0030308 IDA negative regulation of cell growth
GO:0030332 IEA cyclin binding
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031100 IEA organ regeneration
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031668 IMP cellular response to extracellular stimulus
GO:0032403 IEA protein complex binding
GO:0033158 IEA regulation of protein import into nucleus, translocation
GO:0034605 IEA cellular response to heat
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042326 IDA negative regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0042771 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066 IEA negative regulation of apoptotic process
GO:0043068 IEA positive regulation of programmed cell death
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045087 TAS innate immune response
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046685 IEA response to arsenic-containing substance
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051384 IEA response to glucocorticoid
GO:0051412 IEA response to corticosterone
GO:0051726 IEA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0060574 IEA intestinal epithelial cell maturation
GO:0070557 IDA PCNA-p21 complex
GO:0071479 IMP cellular response to ionizing radiation
GO:0071850 IEA mitotic cell cycle arrest
GO:0090398 IMP cellular senescence
GO:0090400 TAS stress-induced premature senescence
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:2000278 IEA regulation of DNA biosynthetic process
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000122348 Cdkn1a-002 protein_coding Mus_musculus 0 311
ENSMUST00000023829 Cdkn1a-001 protein_coding Mus_musculus 0 309
ENSMUST00000119901 Cdkn1a-003 protein_coding Mus_musculus 0 309

Loading