C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protection of telomeres 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128513 POT1 9606 - 7:124822386-124929983 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357628 POT1-001 124822386-124929981 protein_coding
  ENST00000393329 POT1-201 124822387-124929983 protein_coding
  ENST00000429326 POT1-006 124858978-124897202 nonsense_mediated_decay
  ENST00000430927 POT1-009 124822386-124827250 nonsense_mediated_decay
  ENST00000436534 POT1-008 124822401-124829342 protein_coding
  ENST00000446993 POT1-003 124870919-124929944 protein_coding
  ENST00000461288 POT1-004 124898261-124929802 processed_transcript
  ENST00000464453 POT1-005 124928921-124929786 processed_transcript
  ENST00000466483 POT1-007 124840981-124843249 retained_intron
  ENST00000487564 POT1-010 124858781-124863385 protein_coding
  ENST00000607932 POT1-011 124823962-124897184 nonsense_mediated_decay
  ENST00000608057 POT1-012 124823962-124897184 nonsense_mediated_decay
  ENST00000608126 POT1-015 124851926-124853527 retained_intron
  ENST00000608200 POT1-016 124840656-124842832 protein_coding
  ENST00000608261 POT1-018 124892726-124929825 processed_transcript
  ENST00000608437 POT1-017 124892374-124929825 processed_transcript
  ENST00000609106 POT1-019 124823856-124929802 nonsense_mediated_decay
  ENST00000609702 POT1-013 124870945-124929827 protein_coding
  ENST00000610141 POT1-014 124851808-124859050 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000357628ENST00000393329ENST00000429326ENST00000430927ENST00000446993ENST00000466483ENST00000487564ENST00000607932ENST00000608057ENST00000608261ENST00000609106
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000357628 N/A N/A N/A N/A N/A 0.622±0.00 N/A 1.451±0.00 1.279±0.50 0.540±0.00 N/A 0.793±0.53 0.290±0.07 N/A
ENST00000393329 0.835±0.00 1.368±0.00 0.541±0.00 1.220±0.00 1.235±0.00 1.062±0.00 0.849±0.00 0.712±0.00 N/A 0.788±0.00 0.171±0.00 0.614±0.10 0.592±0.02 2.556±0.57
ENST00000429326 N/A N/A 1.588±0.00 N/A N/A N/A N/A N/A N/A N/A 1.654±0.00 N/A N/A N/A
ENST00000430927 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.181±0.00 N/A N/A N/A N/A
ENST00000446993 N/A N/A N/A N/A 1.621±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000466483 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.899±0.00 N/A N/A N/A
ENST00000487564 N/A N/A N/A N/A N/A 4.723±0.00 N/A N/A N/A N/A 2.637±0.00 N/A N/A N/A
ENST00000607932 N/A 1.420±0.00 N/A N/A 0.847±0.00 1.037±0.14 1.911±0.00 1.513±0.00 N/A 1.552±0.32 0.118±0.00 1.578±0.52 0.775±0.00 N/A
ENST00000608057 1.472±0.00 1.006±0.00 N/A 3.101±0.00 2.126±0.00 0.836±0.00 1.159±0.00 2.071±0.00 0.592±0.00 N/A N/A 0.918±0.00 0.933±0.24 3.699±0.35
ENST00000608261 N/A N/A N/A N/A N/A 2.582±0.00 2.942±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000609106 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.058±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001OL CIL_0001OL_0001 CGP 7:124822386-127253294

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000723 IEA:TAS telomere maintenance
GO:0000781 IDA chromosome, telomeric region
GO:0000783 IDA nuclear telomere cap complex
GO:0000784 IEA nuclear chromosome, telomeric region
GO:0003677 IEA DNA binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0007004 IDA telomere maintenance via telomerase
GO:0010521 IDA telomerase inhibitor activity
GO:0016233 IMP telomere capping
GO:0017151 IPI DEAD/H-box RNA helicase binding
GO:0032203 IDA telomere formation via telomerase
GO:0032211 IMP negative regulation of telomere maintenance via telomerase
GO:0032212 IMP positive regulation of telomere maintenance via telomerase
GO:0032508 IDA DNA duplex unwinding
GO:0043047 IEA:IMP single-stranded telomeric DNA binding
GO:0051096 IDA positive regulation of helicase activity
GO:0051973 IDA positive regulation of telomerase activity
GO:0051974 IDA negative regulation of telomerase activity
GO:0060383 IDA positive regulation of DNA strand elongation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079915 pot1 protection of telomeres 1 homolog protein_coding Danio_rerio
ENSMUSG00000024174 Pot1b protection of telomeres 1B protein_coding Mus_musculus
ENSMUSG00000029676 Pot1a protection of telomeres 1A protein_coding Mus_musculus

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