C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: delta-like 4 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128917 DLL4 9606 + 15:40929340-40939072 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000249749 DLL4-001 40929393-40939072 protein_coding
  ENST00000557876 DLL4-002 40929340-40930890 retained_intron
  ENST00000559440 DLL4-003 40930880-40934921 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000249749
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000249749 20.172±0.00 9.350±0.00 0.499±0.38 4.869±1.78 6.364±5.36 3.540±2.10 1.318±0.75 1.295±0.52 21.514±17.85 1.090±0.50 4.742±2.21 10.438±2.28 1.846±0.42

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000799 CIL_000799_0001 CGP 15:40894430-40939072
CIL_0005IN CIL_0005IN_0002 CGP 15:40929340-40956519

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001525 ISS angiogenesis
GO:0001569 ISS patterning of blood vessels
GO:0001974 ISS blood vessel remodeling
GO:0003208 ISS cardiac ventricle morphogenesis
GO:0003209 ISS cardiac atrium morphogenesis
GO:0003222 ISS ventricular trabecula myocardium morphogenesis
GO:0003344 ISS pericardium morphogenesis
GO:0005112 IEA Notch binding
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005886 TAS plasma membrane
GO:0007154 IEA cell communication
GO:0007165 TAS signal transduction
GO:0007219 TAS:IEA Notch signaling pathway
GO:0007220 TAS Notch receptor processing
GO:0007275 IEA multicellular organismal development
GO:0007601 IEA visual perception
GO:0008015 TAS blood circulation
GO:0008285 IMP negative regulation of cell proliferation
GO:0010596 IMP negative regulation of endothelial cell migration
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0035912 ISS dorsal aorta morphogenesis
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0043537 IEA negative regulation of blood vessel endothelial cell migration
GO:0044344 IDA cellular response to fibroblast growth factor stimulus
GO:0050767 IEA regulation of neurogenesis
GO:0060579 IMP ventral spinal cord interneuron fate commitment
GO:0061074 ISS regulation of neural retina development
GO:0061314 ISS Notch signaling involved in heart development
GO:0072554 IEA blood vessel lumenization
GO:0090051 IMP negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179 ISS positive regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070425 dll4 delta-like 4 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000027314 Dll4 delta-like 4 (Drosophila) protein_coding Mus_musculus

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