C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: delta-like 4 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027314 Dll4 10090 + 2:119325784-119335962 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000102517 Dll4-001 119325784-119335962 protein_coding
  ENSMUST00000127102 Dll4-002 119328538-119332153 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000102517ENSMUST00000127102
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000102517 16.493±7.17 7.184±1.83 2.649±0.24 1.738±1.03 6.765±2.80 7.183±0.46 6.687±0.85 4.824±0.69 1.100±0.29 37.348±11.00 2.015±0.34 6.935±2.17 2.012±0.52 0.223±0.08
ENSMUST00000127102 N/A N/A N/A N/A 3.708±0.00 N/A 6.037±1.54 5.030±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000799 CIL_000799_0002 CGP 2:119288740-119335962
CIL_0005IN CIL_0005IN_0003 CGP 2:119325784-119354381

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IMP angiogenesis
GO:0001569 IMP patterning of blood vessels
GO:0001974 IMP blood vessel remodeling
GO:0003208 IMP cardiac ventricle morphogenesis
GO:0003209 IMP cardiac atrium morphogenesis
GO:0003222 IMP ventricular trabecula myocardium morphogenesis
GO:0003344 IMP pericardium morphogenesis
GO:0005112 IDA Notch binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005886 TAS plasma membrane
GO:0005887 ISS integral component of plasma membrane
GO:0007601 IEA visual perception
GO:0008285 ISS negative regulation of cell proliferation
GO:0010596 ISS negative regulation of endothelial cell migration
GO:0035912 IMP dorsal aorta morphogenesis
GO:0035924 ISS cellular response to vascular endothelial growth factor stimulus
GO:0043537 IDA negative regulation of blood vessel endothelial cell migration
GO:0044344 ISS cellular response to fibroblast growth factor stimulus
GO:0050767 IMP regulation of neurogenesis
GO:0060579 ISS ventral spinal cord interneuron fate commitment
GO:0061074 IMP regulation of neural retina development
GO:0061314 IMP Notch signaling involved in heart development
GO:0072554 IMP blood vessel lumenization
GO:0090051 ISS negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179 IMP positive regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070425 dll4 delta-like 4 (Drosophila) protein_coding Danio_rerio
ENSG00000128917 DLL4 delta-like 4 (Drosophila) protein_coding Homo_sapiens

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