C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: egl-9 family hypoxia-inducible factor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129521 EGLN3 9606 - 14:33924231-34462774 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250457 EGLN3-001 33924231-33951081 protein_coding
  ENST00000464521 EGLN3-003 34126253-34169766 processed_transcript
  ENST00000487915 EGLN3-006 33929099-34222877 protein_coding
  ENST00000546681 EGLN3-009 34096163-34227814 processed_transcript
  ENST00000547327 EGLN3-005 33948233-33951081 protein_coding
  ENST00000548285 EGLN3-002 34092317-34222953 processed_transcript
  ENST00000550114 EGLN3-010 33985153-34018655 processed_transcript
  ENST00000551935 EGLN3-011 33985381-34462774 processed_transcript
  ENST00000553215 EGLN3-004 33925399-33950826 protein_coding
  ENST00000556785 EGLN3-013 33925511-33931336 retained_intron
  ENST00000557521 EGLN3-012 34127029-34130044 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000250457ENST00000547327ENST00000553215ENST00000556785
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000250457 2.533±0.00 4.448±0.00 1.312±0.00 4.335±1.06 1.301±0.71 2.483±1.19 9.990±6.80 0.730±0.48 3.359±3.27 0.938±0.12 1.248±0.66 2.420±1.19 10.813±4.56 0.997±0.63
ENST00000547327 0.524±0.00 N/A 0.392±0.00 0.792±0.00 0.371±0.00 0.953±0.44 1.427±0.00 N/A 2.807±0.00 0.979±0.56 N/A 1.104±0.90 2.521±1.20 0.101±0.00
ENST00000553215 3.164±0.00 5.663±0.00 N/A 9.883±0.00 0.945±0.00 11.468±0.00 24.557±0.00 3.393±0.00 0.363±0.00 4.712±0.00 4.469±0.00 1.808±0.64 N/A 2.099±1.88
ENST00000556785 N/A N/A N/A 4.422±0.00 1.444±0.00 4.303±0.00 4.937±0.00 N/A 3.703±3.61 2.590±0.00 0.415±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007M4 CIL_0007M4_0001 UCNEbase 14:32599473-34309899
CIL_0005RA CIL_0005RA_0002 CGP 14:32934933-34462774
CIL_0008MA CIL_0008MA_0001 VISTA 14:33353122-33953826
CIL_0008M9 CIL_0008M9_0001 VISTA 14:33432900-34033923
CIL_0009C2 CIL_0009C2_0001 VISTA 14:33616095-34217628
CIL_0005R9 CIL_0005R9_0002 CGP 14:33924231-34462774

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEP response to hypoxia
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006915 IEP apoptotic process
GO:0006919 IEP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0016491 IEA oxidoreductase activity
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0018126 IDA protein hydroxylation
GO:0018401 IDA peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0031418 IEA L-ascorbic acid binding
GO:0031545 IDA peptidyl-proline 4-dioxygenase activity
GO:0042127 IEP regulation of cell proliferation
GO:0043523 ISS regulation of neuron apoptotic process
GO:0055114 IEA oxidation-reduction process
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 TAS cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032553 egln3 egl nine homolog 3 (C. elegans) protein_coding Danio_rerio
ENSMUSG00000035105 Egln3 egl-9 family hypoxia-inducible factor 3 protein_coding Mus_musculus

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