C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 16
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000130762 ARHGEF16 9606 + 1:3454426-3481113 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000378371 ARHGEF16-003 3466971-3481113 protein_coding
  ENST00000378373 ARHGEF16-002 3466005-3481113 protein_coding
  ENST00000378378 ARHGEF16-001 3454426-3481113 protein_coding
  ENST00000418137 ARHGEF16-007 3471624-3476019 protein_coding
  ENST00000445297 ARHGEF16-005 3468544-3473521 protein_coding
  ENST00000464620 ARHGEF16-006 3471607-3474457 retained_intron
  ENST00000485984 ARHGEF16-004 3472769-3481113 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378371ENST00000378373ENST00000378378ENST00000445297ENST00000485984
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378371 0.273±0.00 N/A N/A 0.441±0.00 N/A N/A N/A N/A N/A 0.734±0.00 N/A 2.380±0.00 N/A 1.100±0.00
ENST00000378373 0.230±0.00 N/A N/A 0.125±0.00 1.546±0.27 0.761±0.00 N/A 0.529±0.00 N/A N/A N/A N/A N/A N/A
ENST00000378378 0.246±0.00 0.081±0.00 0.803±0.00 0.123±0.00 0.464±0.15 0.820±0.00 0.138±0.00 3.793±3.54 0.680±0.44 1.212±1.00 0.501±0.00 6.510±7.59 5.381±2.12 1.604±0.00
ENST00000445297 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.793±0.00 N/A N/A
ENST00000485984 N/A N/A N/A N/A N/A N/A N/A 1.643±0.00 N/A N/A N/A 18.579±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007TB CIL_0007TB_0001 VISTA 1:2974017-3574864
CIL_00099V CIL_00099V_0001 VISTA 1:3045529-3649801

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA:IDA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0007264 TAS small GTPase mediated signal transduction
GO:0017048 IPI Rho GTPase binding
GO:0030165 IPI PDZ domain binding
GO:0030971 IPI receptor tyrosine kinase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032863 IMP activation of Rac GTPase activity
GO:0032864 IDA activation of Cdc42 GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0060326 IMP cell chemotaxis
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077114 arhgef16 Rho guanine nucleotide exchange factor (GEF) 16 protein_coding Danio_rerio
ENSMUSG00000029032 Arhgef16 Rho guanine nucleotide exchange factor (GEF) 16 protein_coding Mus_musculus

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