C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 16
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000378378 ARHGEF16-001 ENSG00000130762 9606 + 1:3454426-3481113 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378378
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378378 0.246±0.00 0.081±0.00 0.803±0.00 0.123±0.00 0.464±0.15 0.820±0.00 0.138±0.00 3.793±3.54 0.680±0.44 1.212±1.00 0.501±0.00 6.510±7.59 5.381±2.12 1.604±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007TB CIL_0007TB_0001 VISTA 1:2974017-3574864
CIL_00099V CIL_00099V_0001 VISTA 1:3045529-3649801

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 IEA:IDA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0007264 TAS small GTPase mediated signal transduction
GO:0017048 IPI Rho GTPase binding
GO:0030165 IPI PDZ domain binding
GO:0030971 IPI receptor tyrosine kinase binding
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032863 IMP activation of Rac GTPase activity
GO:0032864 IDA activation of Cdc42 GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0060326 IMP cell chemotaxis
GO:0090004 IMP positive regulation of establishment of protein localization to plasma membrane
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000169623 Arhgef16-201 protein_coding Mus_musculus 0 1707
ENSMUST00000030898 Arhgef16-001 protein_coding Mus_musculus 0 1707
ENSMUST00000144145 Arhgef16-003 retained_intron Mus_musculus 0 656
ENSMUST00000129189 Arhgef16-005 processed_transcript Mus_musculus 0 536

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